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NU3M_MYXGL
ID   NU3M_MYXGL              Reviewed;         115 AA.
AC   Q9G2X1; O63919;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 3;
GN   Name=MT-ND3; Synonyms=MTND3, NADH3, ND3;
OS   Myxine glutinosa (Atlantic hagfish).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Myxini;
OC   Myxiniformes; Myxinidae; Myxininae; Myxine.
OX   NCBI_TaxID=7769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9541532; DOI=10.1007/pl00006317;
RA   Rasmussen A.S., Janke A., Arnason U.;
RT   "The mitochondrial DNA molecule of the hagfish (Myxine glutinosa) and
RT   vertebrate phylogeny.";
RL   J. Mol. Evol. 46:382-388(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11677623; DOI=10.1007/s002390010250;
RA   Delarbre C., Rasmussen A.S., Arnason U., Gachelin G.;
RT   "The complete mitochondrial genome of the hagfish Myxine glutinosa: unique
RT   features of the control region.";
RL   J. Mol. Evol. 53:634-641(2001).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR   EMBL; Y15188; CAA75487.2; -; Genomic_DNA.
DR   EMBL; AJ404477; CAC20656.1; -; Genomic_DNA.
DR   RefSeq; NP_073280.1; NC_002639.1.
DR   AlphaFoldDB; Q9G2X1; -.
DR   SMR; Q9G2X1; -.
DR   GeneID; 802352; -.
DR   CTD; 4537; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   PANTHER; PTHR11058; PTHR11058; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..115
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000117767"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        28
FT                   /note="V -> I (in Ref. 1; CAA75487)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        83
FT                   /note="S -> A (in Ref. 1; CAA75487)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        87
FT                   /note="A -> S (in Ref. 1; CAA75487)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   115 AA;  13086 MW;  17354C06E19BB7FF CRC64;
     MITLHMVVLP FLITLFLLLI IKFLPMNVPD KEKLSPYECG FDPSGSARLP FSMKFFLVAI
     LFILFDLEII LLFPLAWALN SQSHSNAIIL ASVFVIILTL GLIYEWLKGG LEWTE
 
 
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