NU3M_MYXGL
ID NU3M_MYXGL Reviewed; 115 AA.
AC Q9G2X1; O63919;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=MT-ND3; Synonyms=MTND3, NADH3, ND3;
OS Myxine glutinosa (Atlantic hagfish).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Myxini;
OC Myxiniformes; Myxinidae; Myxininae; Myxine.
OX NCBI_TaxID=7769;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9541532; DOI=10.1007/pl00006317;
RA Rasmussen A.S., Janke A., Arnason U.;
RT "The mitochondrial DNA molecule of the hagfish (Myxine glutinosa) and
RT vertebrate phylogeny.";
RL J. Mol. Evol. 46:382-388(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11677623; DOI=10.1007/s002390010250;
RA Delarbre C., Rasmussen A.S., Arnason U., Gachelin G.;
RT "The complete mitochondrial genome of the hagfish Myxine glutinosa: unique
RT features of the control region.";
RL J. Mol. Evol. 53:634-641(2001).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; Y15188; CAA75487.2; -; Genomic_DNA.
DR EMBL; AJ404477; CAC20656.1; -; Genomic_DNA.
DR RefSeq; NP_073280.1; NC_002639.1.
DR AlphaFoldDB; Q9G2X1; -.
DR SMR; Q9G2X1; -.
DR GeneID; 802352; -.
DR CTD; 4537; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..115
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117767"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 28
FT /note="V -> I (in Ref. 1; CAA75487)"
FT /evidence="ECO:0000305"
FT CONFLICT 83
FT /note="S -> A (in Ref. 1; CAA75487)"
FT /evidence="ECO:0000305"
FT CONFLICT 87
FT /note="A -> S (in Ref. 1; CAA75487)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 115 AA; 13086 MW; 17354C06E19BB7FF CRC64;
MITLHMVVLP FLITLFLLLI IKFLPMNVPD KEKLSPYECG FDPSGSARLP FSMKFFLVAI
LFILFDLEII LLFPLAWALN SQSHSNAIIL ASVFVIILTL GLIYEWLKGG LEWTE
