NU3M_OENBE
ID NU3M_OENBE Reviewed; 118 AA.
AC P18630;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=ND3; Synonyms=NAD3;
OS Oenothera berteroana (Bertero's evening primrose).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Onagraceae; Onagroideae; Onagreae; Oenothera.
OX NCBI_TaxID=3950;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND RNA EDITING.
RC STRAIN=cv. Munzia;
RX PubMed=1688531; DOI=10.1002/j.1460-2075.1990.tb08104.x;
RA Schuster W., Wissinger B., Unseld M., Brennicke A.;
RT "Transcripts of the NADH-dehydrogenase subunit 3 gene are differentially
RT edited in Oenothera mitochondria.";
RL EMBO J. 9:263-269(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- RNA EDITING: Modified_positions=2 {ECO:0000269|PubMed:1688531}, 15
CC {ECO:0000269|PubMed:1688531}, 49 {ECO:0000269|PubMed:1688531}, 70
CC {ECO:0000269|PubMed:1688531}, 72 {ECO:0000269|PubMed:1688531}, 83
CC {ECO:0000269|PubMed:1688531}, 84 {ECO:0000269|PubMed:1688531}, 89
CC {ECO:0000269|PubMed:1688531}, 92 {ECO:0000269|PubMed:1688531}, 106
CC {ECO:0000269|PubMed:1688531}, 115 {ECO:0000269|PubMed:1688531}, 117
CC {ECO:0000269|PubMed:1688531};
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X52199; CAA36452.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X52200; CAA36454.1; -; mRNA.
DR AlphaFoldDB; P18630; -.
DR SMR; P18630; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.58.1610; -; 1.
DR HAMAP; MF_01394; NDH1_NuoA; 1.
DR InterPro; IPR023043; NAD(P)H_OxRDtase_bac/plastid.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW RNA editing; Translocase; Transmembrane; Transmembrane helix; Transport;
KW Ubiquinone.
FT CHAIN 1..118
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117774"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 118 AA; 13755 MW; FD444ACD5CC30A32 CRC64;
MLEFAPICIS LVISLLLSLI LLVVPFLFSS NSSTYPEKLS AYECGFDPFG DARSRFDIRF
YLVSILFIIF DLEVTFFFPW AVSFNKIDLF GFWSMMAFLL ILTIGFLYEW KRGALDWE
