NU3M_ONCMA
ID NU3M_ONCMA Reviewed; 116 AA.
AC Q37108; Q35270;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=MT-ND3; Synonyms=MTND3, NADH3, ND3;
OS Oncorhynchus masou (Cherry salmon) (Masu salmon).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8020;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RA McKay S.J., Devlin R.H., Smith M.J.;
RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8688811; DOI=10.2108/zsj.13.189;
RA Oohara I., Okazaki T.;
RT "Genetic relationship among three subspecies of Oncorhynchus masou
RT determined by mitochondrial DNA sequence analysis.";
RL Zool. Sci. 13:189-198(1996).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; U28363; AAB05094.1; -; Genomic_DNA.
DR EMBL; U28364; AAB05092.1; -; Genomic_DNA.
DR EMBL; D63410; BAA09712.1; -; Genomic_DNA.
DR EMBL; D63335; BAA09650.1; -; Genomic_DNA.
DR EMBL; D63336; BAA09654.1; -; Genomic_DNA.
DR AlphaFoldDB; Q37108; -.
DR SMR; Q37108; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..116
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117778"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 90
FT /note="V -> I (in subspecies Rhodorus)"
SQ SEQUENCE 116 AA; 12864 MW; 676616F822A09E1A CRC64;
MNLITTIITI TITLSAVLAT ISFWLPQISP DAEKLSPYEC GFDPLGSARL PFSLRFFLIA
ILFLLFDLEI ALLLPLPWGD QLNTPALTLV WSTAVLALLT LGLIYEWTQG GLEWAE
