ID   NU3M_ONCMY              Reviewed;         116 AA.
AC   P11629;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 3;
GN   Name=MT-ND3; Synonyms=MTND3, NADH3, ND3;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2550657; DOI=10.1007/bf02100207;
RA   Thomas W.K., Beckenbach A.T.;
RT   "Variation in salmonid mitochondrial DNA: evolutionary constraints and
RT   mechanisms of substitution.";
RL   J. Mol. Evol. 29:233-245(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=8587139; DOI=10.1007/bf00173174;
RA   Zardoya R., Garrido-Pertierra A., Bautista J.M.;
RT   "The complete nucleotide sequence of the mitochondrial DNA genome of the
RT   rainbow trout, Oncorhynchus mykiss.";
RL   J. Mol. Evol. 41:942-951(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-116.
RC   TISSUE=Liver;
RX   PubMed=3265651; DOI=10.1007/bf00521273;
RA   Davidson W.S., Bartlett S.E., Birt T.P., Green J.M.;
RT   "Cloning and sequence analysis of an XbaI fragment of rainbow trout
RT   mitochondrial DNA.";
RL   Curr. Genet. 14:483-486(1988).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L29771; AAB03354.1; -; Genomic_DNA.
DR   EMBL; X14013; CAA32178.1; -; Genomic_DNA.
DR   PIR; E30396; E30396.
DR   RefSeq; NP_008297.1; NC_001717.1.
DR   AlphaFoldDB; P11629; -.
DR   SMR; P11629; -.
DR   GeneID; 807972; -.
DR   KEGG; omy:807972; -.
DR   CTD; 4537; -.
DR   OrthoDB; 1605459at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   PANTHER; PTHR11058; PTHR11058; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..116
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000117779"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        74
FT                   /note="L -> F (in Ref. 3; CAA32178)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        80
FT                   /note="D -> V (in Ref. 3; CAA32178)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   116 AA;  12931 MW;  0C13F2566DA08A4B CRC64;
     MNLITTIITI TITLSAVLAT ISFWLPQISP DAEKLSPYEC GFDPLGSARL PFSLRFFLIA
     ILFLLFDLEI ALLLPLPWGD QLHTPTLTLI WSTAVLALLT LGLIYEWTQG GLEWAE