NU3M_PIG
ID NU3M_PIG Reviewed; 115 AA.
AC O79880;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000250|UniProtKB:P03897};
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897};
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=MT-ND3 {ECO:0000250|UniProtKB:P03897}; Synonyms=MTND3, NADH3, ND3;
OS Sus scrofa (Pig).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9732457; DOI=10.1007/pl00006388;
RA Ursing B.M., Arnason U.;
RT "The complete mitochondrial DNA sequence of the pig (Sus scrofa).";
RL J. Mol. Evol. 47:302-306(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Landrace;
RX PubMed=10433971; DOI=10.1016/s0378-1119(99)00247-4;
RA Lin C.S., Sun Y.L., Liu C.Y., Yang P.C., Chang L.C., Cheng I.C.,
RA Mao S.J.T., Huang M.C.;
RT "Complete nucleotide sequence of pig (Sus scrofa) mitochondrial genome and
RT dating evolutionary divergence within artiodactyla.";
RL Gene 236:107-114(1999).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity of complex I.
CC {ECO:0000250|UniProtKB:P03897}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03897};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits. Interacts with TMEM186.
CC Interacts with TMEM242 (By similarity). {ECO:0000250|UniProtKB:P03897}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; AJ002189; CAA05236.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF034253; AAD34192.1; -; Genomic_DNA.
DR PIR; T10979; T10979.
DR RefSeq; NP_008641.1; NC_000845.1.
DR PDB; 5GPN; EM; 5.40 A; g=1-115.
DR PDB; 5GUP; EM; 4.00 A; j=1-115.
DR PDB; 7V2C; EM; 2.90 A; j=1-115.
DR PDB; 7V2D; EM; 3.30 A; j=1-113.
DR PDB; 7V2E; EM; 2.80 A; j=1-115.
DR PDB; 7V2F; EM; 3.10 A; j=1-113.
DR PDB; 7V2H; EM; 2.50 A; j=1-115.
DR PDB; 7V2K; EM; 2.70 A; j=1-113.
DR PDB; 7V2R; EM; 2.60 A; j=1-115.
DR PDB; 7V30; EM; 2.70 A; j=1-113.
DR PDB; 7V31; EM; 2.90 A; j=1-115.
DR PDB; 7V32; EM; 3.20 A; j=1-113.
DR PDB; 7V33; EM; 2.60 A; j=1-115.
DR PDB; 7V3M; EM; 2.90 A; j=1-113.
DR PDB; 7VBL; EM; 2.60 A; j=1-115.
DR PDB; 7VBP; EM; 2.80 A; j=1-113.
DR PDB; 7VC0; EM; 2.60 A; j=1-115.
DR PDB; 7VWL; EM; 2.70 A; j=1-113.
DR PDBsum; 5GPN; -.
DR PDBsum; 5GUP; -.
DR PDBsum; 7V2C; -.
DR PDBsum; 7V2D; -.
DR PDBsum; 7V2E; -.
DR PDBsum; 7V2F; -.
DR PDBsum; 7V2H; -.
DR PDBsum; 7V2K; -.
DR PDBsum; 7V2R; -.
DR PDBsum; 7V30; -.
DR PDBsum; 7V31; -.
DR PDBsum; 7V32; -.
DR PDBsum; 7V33; -.
DR PDBsum; 7V3M; -.
DR PDBsum; 7VBL; -.
DR PDBsum; 7VBP; -.
DR PDBsum; 7VC0; -.
DR PDBsum; 7VWL; -.
DR AlphaFoldDB; O79880; -.
DR SMR; O79880; -.
DR STRING; 9823.ENSSSCP00000019142; -.
DR PaxDb; O79880; -.
DR PeptideAtlas; O79880; -.
DR Ensembl; ENSSSCT00000019679; ENSSSCP00000019142; ENSSSCG00000018084.
DR Ensembl; ENSSSCT00070061681; ENSSSCP00070052585; ENSSSCG00070030644.
DR GeneID; 808508; -.
DR KEGG; ssc:808508; -.
DR CTD; 4537; -.
DR VGNC; VGNC:99794; MT-ND3.
DR eggNOG; KOG4662; Eukaryota.
DR GeneTree; ENSGT00390000011605; -.
DR HOGENOM; CLU_119549_3_1_1; -.
DR InParanoid; O79880; -.
DR OMA; RFPVKYY; -.
DR OrthoDB; 1605459at2759; -.
DR TreeFam; TF343336; -.
DR Reactome; R-SSC-611105; Respiratory electron transport.
DR Reactome; R-SSC-6799198; Complex I biogenesis.
DR Proteomes; UP000008227; Mitochondrion.
DR Proteomes; UP000314985; Mitochondrion.
DR Bgee; ENSSSCG00000018084; Expressed in hypothalamus and 46 other tissues.
DR ExpressionAtlas; O79880; baseline and differential.
DR Genevisible; O79880; SS.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..115
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117805"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 115 AA; 12994 MW; 0EAFEC0CA3B7F7E4 CRC64;
MNIMLTLLTN VTLASLLVLI AFWLPQLNAY SEKTSPYECG FDPMGSARLP FSMKFFLVAI
TFLLFDLEIA LLLPLPWASQ TNNLKTMLTM ALFLLILLAA SLAYEWTQKG LEWAE
