NU3M_PONPY
ID NU3M_PONPY Reviewed; 115 AA.
AC Q9T9X5; Q5UBR6;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000250|UniProtKB:P03897};
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897};
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=MT-ND3 {ECO:0000250|UniProtKB:P03897}; Synonyms=MTND3, NADH3, ND3;
OS Pongo pygmaeus (Bornean orangutan).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9600;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7530363; DOI=10.1073/pnas.92.2.532;
RA Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
RT "Recent African origin of modern humans revealed by complete sequences of
RT hominoid mitochondrial DNAs.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11080370; DOI=10.1007/s002390010110;
RA Muir C.C., Galdikas B.M.F., Beckenbach A.T.;
RT "mtDNA sequence diversity of orangutans from the islands of Borneo and
RT Sumatra.";
RL J. Mol. Evol. 51:471-480(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Kanthaswamy S., Kurushima J., Alminas O., Von Dollen A.;
RT "Pongo pygmaeus population study.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity of complex I.
CC {ECO:0000250|UniProtKB:P03897}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03897};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits. Interacts with TMEM186.
CC Interacts with TMEM242 (By similarity). {ECO:0000250|UniProtKB:P03897}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; D38115; BAA85290.1; -; Genomic_DNA.
DR EMBL; AF273443; AAG28034.1; -; Genomic_DNA.
DR EMBL; AY764935; AAV34895.1; -; Genomic_DNA.
DR EMBL; AY764936; AAV34896.1; -; Genomic_DNA.
DR EMBL; AY764937; AAV34897.1; -; Genomic_DNA.
DR EMBL; AY764938; AAV34898.1; -; Genomic_DNA.
DR EMBL; AY764939; AAV34899.1; -; Genomic_DNA.
DR EMBL; AY764940; AAV34900.1; -; Genomic_DNA.
DR EMBL; AY764946; AAV34906.1; -; Genomic_DNA.
DR EMBL; AY764948; AAV34908.1; -; Genomic_DNA.
DR EMBL; AY764951; AAV34911.1; -; Genomic_DNA.
DR EMBL; AY764952; AAV34912.1; -; Genomic_DNA.
DR EMBL; AY764953; AAV34913.1; -; Genomic_DNA.
DR EMBL; AY764954; AAV34914.1; -; Genomic_DNA.
DR EMBL; AY764955; AAV34915.1; -; Genomic_DNA.
DR EMBL; AY764956; AAV34916.1; -; Genomic_DNA.
DR EMBL; AY764957; AAV34917.1; -; Genomic_DNA.
DR EMBL; AY764958; AAV34918.1; -; Genomic_DNA.
DR EMBL; AY764963; AAV34923.1; -; Genomic_DNA.
DR EMBL; AY764964; AAV34924.1; -; Genomic_DNA.
DR EMBL; AY764965; AAV34925.1; -; Genomic_DNA.
DR EMBL; AY764966; AAV34926.1; -; Genomic_DNA.
DR EMBL; AY764967; AAV34927.1; -; Genomic_DNA.
DR EMBL; AY764968; AAV34928.1; -; Genomic_DNA.
DR EMBL; AY764969; AAV34929.1; -; Genomic_DNA.
DR EMBL; AY764971; AAV34931.1; -; Genomic_DNA.
DR EMBL; AY764972; AAV34932.1; -; Genomic_DNA.
DR EMBL; AY764973; AAV34933.1; -; Genomic_DNA.
DR EMBL; AY764974; AAV34934.1; -; Genomic_DNA.
DR EMBL; AY764975; AAV34935.1; -; Genomic_DNA.
DR EMBL; AY764976; AAV34936.1; -; Genomic_DNA.
DR EMBL; AY764977; AAV34937.1; -; Genomic_DNA.
DR EMBL; AY764978; AAV34938.1; -; Genomic_DNA.
DR EMBL; AY764979; AAV34939.1; -; Genomic_DNA.
DR EMBL; AY764980; AAV34940.1; -; Genomic_DNA.
DR EMBL; AY764981; AAV34941.1; -; Genomic_DNA.
DR EMBL; AY764982; AAV34942.1; -; Genomic_DNA.
DR EMBL; AY764984; AAV34944.1; -; Genomic_DNA.
DR EMBL; AY764985; AAV34945.1; -; Genomic_DNA.
DR EMBL; AY764986; AAV34946.1; -; Genomic_DNA.
DR EMBL; AY764987; AAV34947.1; -; Genomic_DNA.
DR EMBL; AY764988; AAV34948.1; -; Genomic_DNA.
DR EMBL; AY764990; AAV34950.1; -; Genomic_DNA.
DR EMBL; AY764989; AAV34949.1; -; Genomic_DNA.
DR EMBL; AY764991; AAV34951.1; -; Genomic_DNA.
DR RefSeq; NP_008232.1; NC_001646.1.
DR AlphaFoldDB; Q9T9X5; -.
DR SMR; Q9T9X5; -.
DR GeneID; 807902; -.
DR CTD; 4537; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..115
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117813"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 4
FT /note="V -> I"
FT /id="VAR_025015"
SQ SEQUENCE 115 AA; 13190 MW; 108B4C08F39BA77B CRC64;
MNFVLALTIN TLLALLLMIL TFWLPQLNPY MEKSDPYECG FDPAYPARIP FSMKFFLVAI
TFLLFDLEIA LLLPLPWALQ TTNLPLMTTS SLMLIIILAL GLTYEWSQKG LDWTE
