ID   NU3M_RABIT              Reviewed;         115 AA.
AC   O79434;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000250|UniProtKB:P03897};
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897};
DE   AltName: Full=NADH dehydrogenase subunit 3;
GN   Name=MT-ND3 {ECO:0000250|UniProtKB:P03897}; Synonyms=MTND3, NADH3, ND3;
OS   Oryctolagus cuniculus (Rabbit).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000312|Proteomes:UP000001811};
RX   PubMed=9653643; DOI=10.1006/geno.1998.5282;
RA   Gissi C., Gullberg A., Arnason U.;
RT   "The complete mitochondrial DNA sequence of the rabbit, Oryctolagus
RT   cuniculus.";
RL   Genomics 50:161-169(1998).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity of complex I.
CC       {ECO:0000250|UniProtKB:P03897}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03897};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits. Interacts with TMEM186.
CC       Interacts with TMEM242 (By similarity). {ECO:0000250|UniProtKB:P03897}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR   EMBL; AJ001588; CAA04854.1; -; Genomic_DNA.
DR   PIR; T11487; T11487.
DR   RefSeq; NP_007556.1; NC_001913.1.
DR   AlphaFoldDB; O79434; -.
DR   SMR; O79434; -.
DR   STRING; 9986.ENSOCUP00000026186; -.
DR   Ensembl; ENSOCUT00000033130; ENSOCUP00000026186; ENSOCUG00000029105.
DR   GeneID; 808221; -.
DR   KEGG; ocu:808221; -.
DR   CTD; 4537; -.
DR   eggNOG; KOG4662; Eukaryota.
DR   GeneTree; ENSGT00390000011605; -.
DR   HOGENOM; CLU_119549_3_1_1; -.
DR   InParanoid; O79434; -.
DR   OMA; RFPVKYY; -.
DR   OrthoDB; 1605459at2759; -.
DR   TreeFam; TF343336; -.
DR   Proteomes; UP000001811; Mitochondrion.
DR   Bgee; ENSOCUG00000029105; Expressed in heart and 17 other tissues.
DR   ExpressionAtlas; O79434; baseline.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   PANTHER; PTHR11058; PTHR11058; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..115
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000117816"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  13068 MW;  FD42897E4840CDF2 CRC64;
     MNLMLVLLIN TTISLVLVTI AFWLPQLNIY SEKSSPYECG FDPMGSARLP FSMKFFLVAI
     TFLLFDLEIA LLLPLPWAAQ FNNLNLVLIM ALMLISILAL GLAYEWIQKG LEWVE