NU3M_SHEEP
ID NU3M_SHEEP Reviewed; 115 AA.
AC O78753;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000250|UniProtKB:P03897};
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897};
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=MT-ND3 {ECO:0000250|UniProtKB:P03897}; Synonyms=MTND3, NADH3, ND3;
OS Ovis aries (Sheep).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Merinolandschaf {ECO:0000312|Proteomes:UP000002356}; TISSUE=Liver;
RX PubMed=9767689; DOI=10.1007/pl00006401;
RA Hiendleder S., Lewalski H., Wassmuth R., Janke A.;
RT "The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries)
RT and comparison with the other major ovine haplotype.";
RL J. Mol. Evol. 47:441-448(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity of complex I.
CC {ECO:0000250|UniProtKB:P03897}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03897};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits. Interacts with TMEM186.
CC Interacts with TMEM242 (By similarity). {ECO:0000250|UniProtKB:P03897}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; AF010406; AAD10102.1; -; Genomic_DNA.
DR PIR; T11057; T11057.
DR RefSeq; NP_008413.1; NC_001941.1.
DR PDB; 5LNK; EM; 3.90 A; A=1-115.
DR PDB; 6Q9B; EM; 3.90 A; D3=1-115.
DR PDB; 6QA9; EM; 4.10 A; D3=1-115.
DR PDB; 6QBX; EM; 4.20 A; D3=1-115.
DR PDB; 6QC2; EM; 4.20 A; D3=1-115.
DR PDB; 6QC3; EM; 4.20 A; D3=1-115.
DR PDB; 6QC4; EM; 4.60 A; D3=1-115.
DR PDB; 6QC5; EM; 4.30 A; D3=1-115.
DR PDB; 6QC6; EM; 4.10 A; D3=1-115.
DR PDB; 6QC7; EM; 4.40 A; D3=1-115.
DR PDB; 6QC8; EM; 4.20 A; D3=1-115.
DR PDB; 6QC9; EM; 5.70 A; D3=1-115.
DR PDB; 6QCA; EM; 6.20 A; D3=1-115.
DR PDB; 6QCF; EM; 6.50 A; D3=1-115.
DR PDB; 6ZKA; EM; 2.50 A; A=1-115.
DR PDB; 6ZKB; EM; 2.90 A; A=1-115.
DR PDB; 6ZKC; EM; 3.10 A; A=1-115.
DR PDB; 6ZKD; EM; 2.70 A; A=1-115.
DR PDB; 6ZKE; EM; 2.60 A; A=1-115.
DR PDB; 6ZKF; EM; 2.80 A; A=1-115.
DR PDB; 6ZKG; EM; 3.40 A; A=1-115.
DR PDB; 6ZKH; EM; 3.00 A; A=1-115.
DR PDB; 6ZKI; EM; 2.80 A; A=1-115.
DR PDB; 6ZKJ; EM; 3.00 A; A=1-115.
DR PDB; 6ZKK; EM; 3.70 A; A=1-115.
DR PDB; 6ZKL; EM; 3.10 A; A=1-115.
DR PDB; 6ZKM; EM; 2.80 A; A=1-115.
DR PDB; 6ZKN; EM; 2.90 A; A=1-115.
DR PDB; 6ZKO; EM; 3.80 A; A=1-115.
DR PDB; 6ZKP; EM; 3.20 A; A=1-115.
DR PDB; 6ZKQ; EM; 3.30 A; A=1-115.
DR PDB; 6ZKR; EM; 3.50 A; A=1-115.
DR PDB; 6ZKS; EM; 3.10 A; A=1-115.
DR PDB; 6ZKT; EM; 2.80 A; A=1-115.
DR PDB; 6ZKU; EM; 3.00 A; A=1-115.
DR PDB; 6ZKV; EM; 2.90 A; A=1-115.
DR PDBsum; 5LNK; -.
DR PDBsum; 6Q9B; -.
DR PDBsum; 6QA9; -.
DR PDBsum; 6QBX; -.
DR PDBsum; 6QC2; -.
DR PDBsum; 6QC3; -.
DR PDBsum; 6QC4; -.
DR PDBsum; 6QC5; -.
DR PDBsum; 6QC6; -.
DR PDBsum; 6QC7; -.
DR PDBsum; 6QC8; -.
DR PDBsum; 6QC9; -.
DR PDBsum; 6QCA; -.
DR PDBsum; 6QCF; -.
DR PDBsum; 6ZKA; -.
DR PDBsum; 6ZKB; -.
DR PDBsum; 6ZKC; -.
DR PDBsum; 6ZKD; -.
DR PDBsum; 6ZKE; -.
DR PDBsum; 6ZKF; -.
DR PDBsum; 6ZKG; -.
DR PDBsum; 6ZKH; -.
DR PDBsum; 6ZKI; -.
DR PDBsum; 6ZKJ; -.
DR PDBsum; 6ZKK; -.
DR PDBsum; 6ZKL; -.
DR PDBsum; 6ZKM; -.
DR PDBsum; 6ZKN; -.
DR PDBsum; 6ZKO; -.
DR PDBsum; 6ZKP; -.
DR PDBsum; 6ZKQ; -.
DR PDBsum; 6ZKR; -.
DR PDBsum; 6ZKS; -.
DR PDBsum; 6ZKT; -.
DR PDBsum; 6ZKU; -.
DR PDBsum; 6ZKV; -.
DR AlphaFoldDB; O78753; -.
DR SMR; O78753; -.
DR STRING; 9940.ENSOARP00000000008; -.
DR Ensembl; ENSOART00000000025; ENSOARP00000000008; ENSOARG00000000025.
DR Ensembl; ENSOART00020000025; ENSOARP00020000008; ENSOARG00020000025.
DR GeneID; 808255; -.
DR KEGG; oas:808255; -.
DR CTD; 4537; -.
DR eggNOG; KOG4662; Eukaryota.
DR HOGENOM; CLU_119549_3_1_1; -.
DR OMA; RFPVKYY; -.
DR OrthoDB; 1605459at2759; -.
DR Proteomes; UP000002356; Mitochondrion.
DR Bgee; ENSOARG00000000025; Expressed in cerebellum and 52 other tissues.
DR ExpressionAtlas; O78753; baseline.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..115
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117831"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 2..23
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 25..27
FT /evidence="ECO:0007829|PDB:6ZKE"
FT TURN 31..34
FT /evidence="ECO:0007829|PDB:6ZKB"
FT STRAND 44..46
FT /evidence="ECO:0007829|PDB:6ZKE"
FT HELIX 53..72
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 75..78
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 84..107
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 111..113
FT /evidence="ECO:0007829|PDB:6ZKD"
SQ SEQUENCE 115 AA; 13103 MW; 84D2FB7A0FE06398 CRC64;
MNLMITLLTN FTLATLLVTI AFWLPQLNVY SEKTSPYECG FDPMGSARLP FSMKFFLVAI
TFLLFDLEIA LLLPLPWASQ TTNLNTMLTM ALLLIFLLAV SLAYEWTQKG LEWTE
