NU3M_TETSU
ID NU3M_TETSU Reviewed; 117 AA.
AC Q36518;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=ND3; Synonyms=NAD3;
OS Tetraselmis subcordiformis (Marine green alga) (Carteria subcordiformis).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes;
OC Chlorodendrophyceae; Chlorodendrales; Chlorodendraceae; Tetraselmis.
OX NCBI_TaxID=3161;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8555450; DOI=10.1007/bf00014979;
RA Kessler U., Zetsche K.;
RT "Physical map and gene organization of the mitochondrial genome from the
RT unicellular green alga Platymonas (Tetraselmis) subcordiformis
RT (Prasinophyceae).";
RL Plant Mol. Biol. 29:1081-1086(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; Z47795; CAA87750.1; -; Genomic_DNA.
DR PIR; S62703; S62703.
DR AlphaFoldDB; Q36518; -.
DR SMR; Q36518; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.58.1610; -; 1.
DR HAMAP; MF_01394; NDH1_NuoA; 1.
DR InterPro; IPR023043; NAD(P)H_OxRDtase_bac/plastid.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..117
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117808"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 117 AA; 13668 MW; 11634AEF4742F694 CRC64;
MIEYLAVLIY FLFSLALASL IIFLSFIFAP QKPDPEKISA YECGFDPFDD ARGKFDIRFY
LVAILFIIFD LEVTFLFPWA VTLGKIGFFG FWTMMAFLII LTIGFIYEWK KGALEWE