NU3M_XENLA
ID NU3M_XENLA Reviewed; 114 AA.
AC P03900;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=mt-nd3; Synonyms=mtnd3, nadh3, nd3;
OS Xenopus laevis (African clawed frog).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=4019494; DOI=10.1016/s0021-9258(17)39303-1;
RA Roe B.A., Ma D.-P., Wilson R.K., Wong J.F.-H.;
RT "The complete nucleotide sequence of the Xenopus laevis mitochondrial
RT genome.";
RL J. Biol. Chem. 260:9759-9774(1985).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; M10217; AAA66465.1; -; Genomic_DNA.
DR PIR; A00425; QXXL3M.
DR RefSeq; NP_008141.1; NC_001573.1.
DR AlphaFoldDB; P03900; -.
DR SMR; P03900; -.
DR GeneID; 2642085; -.
DR KEGG; xla:2642085; -.
DR CTD; 4537; -.
DR Xenbase; XB-GENE-6251960; nd3.
DR OrthoDB; 1605459at2759; -.
DR Proteomes; UP000186698; Mitochondrion MT.
DR Bgee; 2642085; Expressed in blastula and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..114
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117840"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 114 AA; 12924 MW; D7D34DEAB778A030 CRC64;
MTATILMIAM TLSTILAILS FWLPQMTPDM EKLSPYECGF DPLGSMRLPF SMRFFLIAIL
FLLFDLEIAL LLPFPWAAQL NTPSIVILWA ALILTLLTLG LIYEWLQGGL EWAE