NU3M_YARLI
ID NU3M_YARLI Reviewed; 128 AA.
AC Q9B6C7;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=ND3;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX DOI=10.1002/cfg.72;
RA Kerscher S., Durstewitz G., Casaregola S., Gaillardin C., Brandt U.;
RT "The complete mitochondrial genome of Yarrowia lipolytica.";
RL Comp. Funct. Genomics 2:80-90(2001).
RN [2]
RP SUBUNIT.
RX PubMed=15282186; DOI=10.1016/j.bbabio.2004.04.019;
RA Abdrakhmanova A., Zickermann V., Bostina M., Radermacher M., Schagger H.,
RA Kerscher S., Brandt U.;
RT "Subunit composition of mitochondrial complex I from the yeast Yarrowia
RT lipolytica.";
RL Biochim. Biophys. Acta 1658:148-156(2004).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Complex I is composed of 37 different subunits.
CC {ECO:0000269|PubMed:15282186}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; AJ307410; CAC28116.2; -; Genomic_DNA.
DR RefSeq; NP_075446.2; NC_002659.1.
DR PDB; 6GCS; EM; 4.32 A; 3=1-128.
DR PDB; 6H8K; X-ray; 3.79 A; 3=1-110.
DR PDB; 6RFQ; EM; 3.30 A; 3=1-128.
DR PDB; 6RFR; EM; 3.20 A; 3=1-128.
DR PDB; 6RFS; EM; 4.04 A; 3=1-128.
DR PDB; 6Y79; EM; 3.20 A; 3=1-128.
DR PDB; 6YJ4; EM; 2.70 A; A=1-128.
DR PDBsum; 6GCS; -.
DR PDBsum; 6H8K; -.
DR PDBsum; 6RFQ; -.
DR PDBsum; 6RFR; -.
DR PDBsum; 6RFS; -.
DR PDBsum; 6Y79; -.
DR PDBsum; 6YJ4; -.
DR AlphaFoldDB; Q9B6C7; -.
DR SMR; Q9B6C7; -.
DR DIP; DIP-61438N; -.
DR IntAct; Q9B6C7; 2.
DR STRING; 284591.Q9B6C7; -.
DR GeneID; 802603; -.
DR KEGG; yli:YalifMp29; -.
DR InParanoid; Q9B6C7; -.
DR Proteomes; UP000001300; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion; NAD;
KW Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..128
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117841"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 3..14
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 17..25
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 32..34
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 54..79
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 80..82
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 84..86
FT /evidence="ECO:0007829|PDB:6RFR"
FT HELIX 87..108
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 124..127
FT /evidence="ECO:0007829|PDB:6YJ4"
SQ SEQUENCE 128 AA; 14470 MW; CFA47B12022BC752 CRC64;
MNTFIIFIIL IPIVGFALLA VNILLAVYKP YNEKLGAFEC GLTSFNQTRL AFNAAFILVA
ILFLPFDLEI STLLPYVMSI YLVSNYGFTI VLLFLLILII GFVYEINTNA LKINKHNKPN
TDSLIYKL
