NU4C1_THEVB
ID NU4C1_THEVB Reviewed; 529 AA.
AC Q8DKY0;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=NAD(P)H-quinone oxidoreductase chain 4 1 {ECO:0000255|HAMAP-Rule:MF_00491};
DE EC=7.1.1.- {ECO:0000255|HAMAP-Rule:MF_00491};
DE AltName: Full=NAD(P)H dehydrogenase I, chain 4 1 {ECO:0000255|HAMAP-Rule:MF_00491};
DE AltName: Full=NDH-1, chain 4 1 {ECO:0000255|HAMAP-Rule:MF_00491};
GN Name=ndhD1 {ECO:0000255|HAMAP-Rule:MF_00491}; OrderedLocusNames=tll0719;
OS Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1).
OC Bacteria; Cyanobacteria; Pseudanabaenales; Thermosynechococcaceae;
OC Thermosynechococcus.
OX NCBI_TaxID=197221;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-2133 / IAM M-273 / BP-1;
RX PubMed=12240834; DOI=10.1093/dnares/9.4.123;
RA Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S.,
RA Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C.,
RA Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M.,
RA Takeuchi C., Yamada M., Tabata S.;
RT "Complete genome structure of the thermophilic cyanobacterium
RT Thermosynechococcus elongatus BP-1.";
RL DNA Res. 9:123-130(2002).
CC -!- FUNCTION: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-
CC sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC immediate electron acceptor for the enzyme in this species is believed
CC to be plastoquinone. Couples the redox reaction to proton translocation
CC (for every two electrons transferred, four hydrogen ions are
CC translocated across the cytoplasmic membrane), and thus conserves the
CC redox energy in a proton gradient. {ECO:0000255|HAMAP-Rule:MF_00491}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n
CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00491};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n
CC H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00491};
CC -!- INTERACTION:
CC Q8DKY0; Q8DKX9: ndhF1; NbExp=2; IntAct=EBI-629650, EBI-629633;
CC -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane {ECO:0000255|HAMAP-
CC Rule:MF_00491}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00491}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family.
CC {ECO:0000255|HAMAP-Rule:MF_00491}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC08270.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BA000039; BAC08270.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_681508.2; NC_004113.1.
DR RefSeq; WP_011056566.1; NC_004113.1.
DR PDB; 6HUM; EM; 3.34 A; D=1-529.
DR PDB; 6KHI; EM; 3.00 A; D=1-529.
DR PDB; 6KHJ; EM; 3.00 A; D=1-529.
DR PDB; 6L7O; EM; 3.20 A; D=1-529.
DR PDB; 6L7P; EM; 3.60 A; D=1-529.
DR PDB; 6NBQ; EM; 3.10 A; D=1-529.
DR PDB; 6NBX; EM; 3.50 A; D=1-529.
DR PDB; 6NBY; EM; 3.10 A; D=1-529.
DR PDBsum; 6HUM; -.
DR PDBsum; 6KHI; -.
DR PDBsum; 6KHJ; -.
DR PDBsum; 6L7O; -.
DR PDBsum; 6L7P; -.
DR PDBsum; 6NBQ; -.
DR PDBsum; 6NBX; -.
DR PDBsum; 6NBY; -.
DR AlphaFoldDB; Q8DKY0; -.
DR SMR; Q8DKY0; -.
DR IntAct; Q8DKY0; 2.
DR STRING; 197221.22294440; -.
DR TCDB; 3.D.1.8.2; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR EnsemblBacteria; BAC08270; BAC08270; BAC08270.
DR KEGG; tel:tll0719; -.
DR PATRIC; fig|197221.4.peg.759; -.
DR eggNOG; COG1008; Bacteria.
DR OMA; ITRWGNQ; -.
DR OrthoDB; 535707at2; -.
DR Proteomes; UP000000440; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031676; C:plasma membrane-derived thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR HAMAP; MF_00491; NDH1_NuoM; 1.
DR InterPro; IPR022997; NADH_Q_OxRdtase_chain4.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
DR TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; NAD; NADP; Plastoquinone; Quinone;
KW Reference proteome; Thylakoid; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..529
FT /note="NAD(P)H-quinone oxidoreductase chain 4 1"
FT /id="PRO_0000343245"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00491"
FT HELIX 6..18
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 21..23
FT /evidence="ECO:0007829|PDB:6NBQ"
FT STRAND 28..31
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 32..56
FT /evidence="ECO:0007829|PDB:6KHI"
FT STRAND 60..63
FT /evidence="ECO:0007829|PDB:6NBX"
FT STRAND 65..68
FT /evidence="ECO:0007829|PDB:6KHI"
FT STRAND 71..73
FT /evidence="ECO:0007829|PDB:6KHI"
FT TURN 74..77
FT /evidence="ECO:0007829|PDB:6KHI"
FT STRAND 82..84
FT /evidence="ECO:0007829|PDB:6KHI"
FT TURN 86..88
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 89..105
FT /evidence="ECO:0007829|PDB:6KHI"
FT TURN 106..108
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 113..132
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 136..144
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 148..155
FT /evidence="ECO:0007829|PDB:6KHI"
FT STRAND 156..158
FT /evidence="ECO:0007829|PDB:6KHI"
FT STRAND 159..161
FT /evidence="ECO:0007829|PDB:6L7O"
FT HELIX 162..188
FT /evidence="ECO:0007829|PDB:6KHI"
FT STRAND 189..192
FT /evidence="ECO:0007829|PDB:6KHJ"
FT HELIX 198..202
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 210..225
FT /evidence="ECO:0007829|PDB:6KHI"
FT TURN 231..233
FT /evidence="ECO:0007829|PDB:6HUM"
FT HELIX 235..238
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 244..250
FT /evidence="ECO:0007829|PDB:6KHI"
FT TURN 251..259
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 261..264
FT /evidence="ECO:0007829|PDB:6KHI"
FT TURN 265..268
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 271..296
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 303..312
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 315..322
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 326..357
FT /evidence="ECO:0007829|PDB:6KHI"
FT TURN 362..364
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 368..371
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 374..386
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 393..406
FT /evidence="ECO:0007829|PDB:6KHI"
FT STRAND 409..411
FT /evidence="ECO:0007829|PDB:6NBY"
FT HELIX 413..441
FT /evidence="ECO:0007829|PDB:6KHI"
FT STRAND 443..445
FT /evidence="ECO:0007829|PDB:6KHI"
FT TURN 448..453
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 461..479
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 481..483
FT /evidence="ECO:0007829|PDB:6KHI"
FT HELIX 485..498
FT /evidence="ECO:0007829|PDB:6KHI"
SQ SEQUENCE 529 AA; 57809 MW; D563D52DAAC8E11D CRC64;
MSTFPWLTTI ILFPIVAALA IPFIPDPTGK GRPIRWYALA VGLIDFALIV YAFTNFYDLN
TPGMQLWESY DWIPEIGLRW SVGADGLSMP LILLTGFITT LAILAAWPVT LKPRLFYFLM
LAMYGGQIAV FAVQDMLVFF LAWELELIPV YLLLAIWGGH KRQYAATKFI LYTAGSSLFI
LVAGLAMAFY GDTVSFDMQT LAAKDYALGF QLLVYAGFLV AYGVKLPIVP LHTWLPDAHG
EATAPVHMLL AGILLKMGGY ALIRMNVDML PAAHAKFAPV LVILGVVNII YAALTSYAQR
NLKRKIAYSS ISHIGFVLIG IASFTNLGMS GAVLQMVSHG LIGASLFFLV GATYDRTHTL
ILEEMGGVGQ KMKKIFAMFT ACSLASLALP GMSGFVAELM VFIGFATSDA YSLPFRVIVV
FLAAVGVILT PIYLLSMLRE IFYGPENKEL VEHEALVDAE PREVFIIACL LVPIIGIGLY
PKLLTQIYDA TTGQVIARAR EVLPTLAQQT EQPLGILPMV APQLKANAQ
