NU4C_ANTAG
ID NU4C_ANTAG Reviewed; 501 AA.
AC Q85BG0;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=NAD(P)H-quinone oxidoreductase chain 4, chloroplastic;
DE EC=7.1.1.-;
DE AltName: Full=NAD(P)H dehydrogenase, chain 4;
DE AltName: Full=NADH-plastoquinone oxidoreductase chain 4;
GN Name=ndhD;
OS Anthoceros angustus (Hornwort) (Anthoceros formosae).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Anthocerotophyta;
OC Anthocerotopsida; Anthocerotidae; Anthocerotales; Anthocerotaceae;
OC Anthoceros.
OX NCBI_TaxID=48387;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND RNA EDITING.
RX PubMed=12527781; DOI=10.1093/nar/gkg155;
RA Kugita M., Kaneko A., Yamamoto Y., Takeya Y., Matsumoto T., Yoshinaga K.;
RT "The complete nucleotide sequence of the hornwort (Anthoceros formosae)
RT chloroplast genome: insight into the earliest land plants.";
RL Nucleic Acids Res. 31:716-721(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND RNA EDITING.
RC TISSUE=Thallus;
RX PubMed=12711687; DOI=10.1093/nar/gkg327;
RA Kugita M., Yamamoto Y., Fujikawa T., Matsumoto T., Yoshinaga K.;
RT "RNA editing in hornwort chloroplasts makes more than half the genes
RT functional.";
RL Nucleic Acids Res. 31:2417-2423(2003).
RN [3]
RP SEQUENCE REVISION.
RA Yoshinaga K.;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n
CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n
CC H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC -!- RNA EDITING: Modified_positions=1 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 12 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 20 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 33 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 46 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 49 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 73 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 99 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 102 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 129 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 135 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 137 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 178 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 179 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 206 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 242 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 261 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 273 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 293 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 295 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 308 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 309 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 322 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 333 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 334 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 345 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 348 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 375 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 402 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 439 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 479 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 483 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}, 492 {ECO:0000269|PubMed:12527781,
CC ECO:0000269|PubMed:12711687}; Note=The initiator methionine is created
CC by RNA editing. The nonsense codons at positions 33, 333 and 439 have
CC been modified to sense codons.;
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
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DR EMBL; AB086179; BAC55401.2; -; Genomic_DNA.
DR EMBL; AB087485; BAC55501.1; ALT_SEQ; mRNA.
DR RefSeq; NP_777464.1; NC_004543.1.
DR AlphaFoldDB; Q85BG0; -.
DR SMR; Q85BG0; -.
DR GeneID; 2553497; -.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR HAMAP; MF_00491; NDH1_NuoM; 1.
DR InterPro; IPR022997; NADH_Q_OxRdtase_chain4.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
DR TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Membrane; NAD; NADP; Plastid; Plastoquinone; Quinone;
KW RNA editing; Thylakoid; Translocase; Transmembrane; Transmembrane helix.
FT CHAIN 1..501
FT /note="NAD(P)H-quinone oxidoreductase chain 4,
FT chloroplastic"
FT /id="PRO_0000118010"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 501 AA; 55853 MW; 21375F1067BF75DF CRC64;
MSNFPWLTII VLLPISAGLL IPLLPNKGNR IIRWYTLGIC LVEFLLITYI FCNYFHFDNQ
FIELKEDYNW INLLDFHWRL GIDGLSIGLI LLTGFITTLA TLAAWPITRN PRLSYFLMLA
MYSGQVGLFA SQDILLFFFM WELELIPVYL LLSMWGGKRR LYAATKFILY TAGSSVFLLM
GALTMGLYGS DGPTLDFENL ANRSYPIGLE IILYLGFFIA YAVKLPMVPL HTWLPDTHGE
AHYSTCMLLA GILLKMGGYG LIRINMELLS HAHSIFAPWL VVIGAIQIVY SALTSLSQLN
LKRRIAYSSV SHMGFVLIGI GSTTDIGVNG AILQMISHGL IGAALFFSAG VTYDRTRTLF
LNQMGGIATS IPKIFTMFSS FSMASLALPG LSGFVAELMI FLGIVSSQNF SFLFKVVIII
VAATGIILTP IYLLSMLRQM FYGYRIIKNL TSYVTDAGPR EIFIFICLFF PIIGIGFYPK
LVLSLSNSKV ESIISGNFSS K
