NU4C_ARATH
ID NU4C_ARATH Reviewed; 500 AA.
AC P26288; Q9MRT9;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 05-DEC-2001, sequence version 3.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=NAD(P)H-quinone oxidoreductase chain 4, chloroplastic;
DE EC=7.1.1.-;
DE AltName: Full=NAD(P)H dehydrogenase, chain 4;
DE AltName: Full=NADH-plastoquinone oxidoreductase chain 4;
GN Name=ndhD; OrderedLocusNames=AtCg01050;
OS Arabidopsis thaliana (Mouse-ear cress).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10574454; DOI=10.1093/dnares/6.5.283;
RA Sato S., Nakamura Y., Kaneko T., Asamizu E., Tabata S.;
RT "Complete structure of the chloroplast genome of Arabidopsis thaliana.";
RL DNA Res. 6:283-290(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-85.
RX PubMed=1907869; DOI=10.1007/bf00023416;
RA Anderson S.L., McIntosh L.;
RT "Partial conservation of the 5' ndhE-psaC-ndhD 3' gene arrangement of
RT chloroplasts in the cyanobacterium Synechocystis sp. PCC 6803: implications
RT for NDH-D function in cyanobacteria and chloroplasts.";
RL Plant Mol. Biol. 16:487-499(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-52, AND RNA EDITING OF INITIATOR
RP CODON.
RC TISSUE=Leaf;
RX PubMed=11181728; DOI=10.1093/jxb/52.354.179;
RA Lopez-Serrano M., del Campo E.M., Sabater B., Martin M.;
RT "Primary transcripts of ndhD of Liliaceae and Aloaceae require editing of
RT the start and 20th codons.";
RL J. Exp. Bot. 52:179-180(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n
CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n
CC H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC -!- RNA EDITING: Modified_positions=1 {ECO:0000269|PubMed:11181728};
CC Note=The initiator methionine is created by RNA editing.;
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
CC -!- CAUTION: Was originally thought to originate from Synechocystis
CC PCC6803. {ECO:0000305|PubMed:1907869}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA37837.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AP000423; BAA84437.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X53842; CAA37837.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AJ278354; CAB96191.2; -; Genomic_DNA.
DR PIR; S14968; S14968.
DR RefSeq; NP_051109.2; NC_000932.1.
DR AlphaFoldDB; P26288; -.
DR SMR; P26288; -.
DR STRING; 3702.ATCG01050.1; -.
DR TCDB; 3.D.1.8.1; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR PaxDb; P26288; -.
DR PRIDE; P26288; -.
DR ProteomicsDB; 249333; -.
DR EnsemblPlants; ATCG01050.1; ATCG01050.1; ATCG01050.
DR GeneID; 844756; -.
DR Gramene; ATCG01050.1; ATCG01050.1; ATCG01050.
DR KEGG; ath:ArthCp074; -.
DR Araport; ATCG01050; -.
DR eggNOG; KOG4845; Eukaryota.
DR HOGENOM; CLU_007100_4_0_1; -.
DR InParanoid; P26288; -.
DR OrthoDB; 996580at2759; -.
DR BioCyc; ARA:ATCG01050-MON; -.
DR PRO; PR:P26288; -.
DR Proteomes; UP000006548; Chloroplast.
DR ExpressionAtlas; P26288; baseline and differential.
DR Genevisible; P26288; AT.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048039; F:ubiquinone binding; IBA:GO_Central.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR HAMAP; MF_00491; NDH1_NuoM; 1.
DR InterPro; IPR022997; NADH_Q_OxRdtase_chain4.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
DR TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Membrane; NAD; NADP; Plastid; Plastoquinone; Quinone;
KW Reference proteome; RNA editing; Thylakoid; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..500
FT /note="NAD(P)H-quinone oxidoreductase chain 4,
FT chloroplastic"
FT /id="PRO_0000118011"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 27
FT /note="R -> K (in Ref. 2; CAA37837)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 500 AA; 56228 MW; EAF844E83E095DF3 CRC64;
MNDFPWLTII VVFPISAGSL MLFLPHRGNK VNKWYTICIC ILELLLTTYA FCYNFKMDDP
LIQLSEDYKW IDFFDFYWRM GIDGLSIGTI LLTGFITTLA TLAAFPVTRD SRFFHFLMLA
MYSGQIGSFS SRDLLLFFIM WELELIPVYL LLSMWGGKKR LYSATKFILY TAGSSIFLLI
GVLGISLYGS NEPTLNLELL ANKSYPVTLE ILFYIGFLIA FAVKSPIIPL HTWLPDTHGE
AHYSTCMLLA GILLKMGAYG LVRINMELLP HAHSMFSPWL LVVGTIQIIY AASTSPGQRN
LKKRIAYSSV SHMGFIIIGI SSITDPGLNG AILQIISHGF IGAALFFLAG TSYDRIRLVY
LDEMGGMAIS IPKIFTMFTI LSMASLALPG MSGFIAEFIV FFGIITSQKY FLISKIFIIF
VMAIGMILTP IYLLSMLRQM FYGYKLINIK NFSFFDSGPR ELFLSISILL PIIGIGIYPD
FVLSLASDKV ESILSNYFYG
