NU4C_HORVU
ID NU4C_HORVU Reviewed; 500 AA.
AC O03060; A1E9P0; O98695; Q40044;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2001, sequence version 2.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=NAD(P)H-quinone oxidoreductase chain 4, chloroplastic;
DE EC=7.1.1.-;
DE AltName: Full=NAD(P)H dehydrogenase, chain 4;
DE AltName: Full=NADH-plastoquinone oxidoreductase chain 4;
GN Name=ndhD;
OS Hordeum vulgare (Barley).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX NCBI_TaxID=4513;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND RNA EDITING OF POSITION 293.
RC STRAIN=cv. Hassan;
RA del Campo E.M., Sabater B., Martin M.;
RT "Plastid ndhD gene of barley (Hordeum vulgare L.), sequence and transcript
RT editing.";
RL (er) Plant Gene Register PGR97-090(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Hassan; TISSUE=Leaf;
RX PubMed=10666448; DOI=10.1093/nar/28.5.1092;
RA del Campo E.M., Sabater B., Martin M.;
RT "Transcripts of the ndhH-D operon of barley plastids: possible role of
RT unedited site III in splicing of the ndhA intron.";
RL Nucleic Acids Res. 28:1092-1098(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Morex;
RX PubMed=17534593; DOI=10.1007/s00122-007-0567-4;
RA Saski C., Lee S.-B., Fjellheim S., Guda C., Jansen R.K., Luo H.,
RA Tomkins J., Rognli O.A., Daniell H., Clarke J.L.;
RT "Complete chloroplast genome sequences of Hordeum vulgare, Sorghum bicolor
RT and Agrostis stolonifera, and comparative analyses with other grass
RT genomes.";
RL Theor. Appl. Genet. 115:571-590(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.
RA Okkels J.-S., Moeller B.-L.;
RT "A barley chloroplast clone encoding psaC and part of ndhD: RNA editing of
RT the ndhD initiation codon in barley?";
RL Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP LACK OF RNA EDITING OF INITIATION CODON.
RX PubMed=8076816; DOI=10.1016/0378-1119(94)90290-9;
RA Neckermann K., Zeltz P., Igloi G.L., Koessel H., Maier R.M.;
RT "The role of RNA editing in conservation of start codons in chloroplast
RT genomes.";
RL Gene 146:177-182(1994).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n
CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n
CC H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561,
CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192;
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC -!- RNA EDITING: Modified_positions=293 {ECO:0000269|Ref.1};
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA32954.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Y12258; CAA72935.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AJ011848; CAA09817.1; ALT_SEQ; Genomic_DNA.
DR EMBL; EF115541; ABK79462.1; ALT_SEQ; Genomic_DNA.
DR EMBL; L06607; AAA32954.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; O03060; -.
DR SMR; O03060; -.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR HAMAP; MF_00491; NDH1_NuoM; 1.
DR InterPro; IPR022997; NADH_Q_OxRdtase_chain4.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
DR TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Membrane; NAD; NADP; Plastid; Plastoquinone; Quinone;
KW RNA editing; Thylakoid; Translocase; Transmembrane; Transmembrane helix.
FT CHAIN 1..500
FT /note="NAD(P)H-quinone oxidoreductase chain 4,
FT chloroplastic"
FT /id="PRO_0000118014"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 452..468
FT /note="ANFVDSGPRELFILICI -> LCYARCSMDTSYLMFQT (in Ref. 2;
FT CAA09817)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 500 AA; 56339 MW; 08DAFF53F092A7C7 CRC64;
MSYFPWLTIL VVLPIFAGSL IFFLPHKGNK IVRWYTISIC LLEFLLMTYA FCYHFQLEDP
LIQLKEDYKW IDVFDFHWRL GIDGLSLGSI LLTGFITTLA TLAAWPITRN SRLFYFLMLA
MYSGQIGLFS SRDLLLFFIM WELELIPVYL LLSMWGGKRR LYSATKFILY TAGGSIFFLI
GVLGMGLYGS NEPGLDLERL INQSYPATLE ILLYFGFLIA YAVKLPIIPL HTWLPDTHGE
AHYSTCMLLA GILLKMGAYG LIRINMELLP HAHYLFSPWL VIIGAIQIIY AALTSLGQRN
FKKRIAYSSV SHMGFIIIGI GSITNIGLNG AILQILSHGF IGATLFFLAG TASDRMRLVY
LEELGGISIP MPKIFTMFSS FSMASLALPG MSGFVAELVV FFGLITSPKF LLMPKALITF
VMAIGMILTP IYLLSMLRQM FYGYKLFNVP NANFVDSGPR ELFILICIFL PVIGIGIYPD
FVLSLSVDRV EALLSNYYPK
