NU4LM_ANOGA
ID NU4LM_ANOGA Reviewed; 99 AA.
AC P34858;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 2.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=mt:ND4L; Synonyms=ND4L;
OS Anopheles gambiae (African malaria mosquito).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G3;
RX PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA Beard C.B., Hamm D.M., Collins F.H.;
RT "The mitochondrial genome of the mosquito Anopheles gambiae: DNA sequence,
RT genome organization, and comparisons with mitochondrial sequences of other
RT insects.";
RL Insect Mol. Biol. 2:103-124(1993).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD12199.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L20934; AAD12199.1; ALT_INIT; Genomic_DNA.
DR PIR; T09810; T09810.
DR RefSeq; NP_008078.1; NC_002084.1.
DR AlphaFoldDB; P34858; -.
DR SMR; P34858; -.
DR STRING; 7165.AGAP028383-PA; -.
DR GeneID; 1267422; -.
DR KEGG; aga:ND4L; -.
DR CTD; 4539; -.
DR VEuPathDB; VectorBase:AGAP028383; -.
DR eggNOG; KOG4669; Eukaryota.
DR HOGENOM; CLU_182394_0_0_1; -.
DR InParanoid; P34858; -.
DR OrthoDB; 1538435at2759; -.
DR Proteomes; UP000007062; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..99
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000118383"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 99 AA; 11779 MW; 3AF5AA7FC7B236C0 CRC64;
MANMFLMFYL SMIMFLFGCM VFVSNRKHLL STLLSLEYMV LSLFIFLFFY LNFMNYETYF
SMFFLTFCVC EGVLGLSILV SMIRTHGNDY FQSFSILQC
