NU4LM_AVACL
ID NU4LM_AVACL Reviewed; 98 AA.
AC A8DQK8; A8DQK4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 25-MAY-2022, entry version 38.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS Avahi cleesei (Cleese's woolly lemur) (Bemaraha woolly lemur).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Avahi.
OX NCBI_TaxID=402244;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate BEMA12, Isolate BEMA13, Isolate BEMA14, Isolate BEMA8, and
RC Isolate BEMA9;
RA Andriantompohavana R., Lei R., Zaonarivelo J.R., Engberg S.E.,
RA Nalanirina G., McGuire S.M., Shore G.D., Andrianasolo J., Herrington K.,
RA Brenneman R.A., Louis E.E. Jr.;
RT "Molecular phylogeny and taxonomic revision of the woolly lemurs, genus
RT Avahi (primates: lemuriformes).";
RL Spec. Publ. Mus. Tex. Tech. Univ. 51:1-64(2007).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. {ECO:0000250|UniProtKB:P03902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03902}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; DQ856113; ABI54996.1; -; Genomic_DNA.
DR EMBL; DQ856114; ABI55000.1; -; Genomic_DNA.
DR EMBL; DQ856115; ABI55004.1; -; Genomic_DNA.
DR EMBL; DQ856116; ABI55008.1; -; Genomic_DNA.
DR EMBL; DQ856117; ABI55012.1; -; Genomic_DNA.
DR AlphaFoldDB; A8DQK8; -.
DR SMR; A8DQK8; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..98
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000323386"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 58
FT /note="M -> T (in strain: Isolate BEMA8)"
SQ SEQUENCE 98 AA; 10803 MW; F4975E5AF7A5D994 CRC64;
MTPIFTNIIL AFATAFLGTL IFRSHLMSSL LCLEGMMLSL FILSTLIILN MHLTVSFMMP
ILLLVFAACE AAIGLALLVM VSNTYGLDYI KNLNLLQC
