NU4LM_AVAUN
ID NU4LM_AVAUN Reviewed; 98 AA.
AC A8DQI8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS Avahi unicolor (Sambirano woolly lemur).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Avahi.
OX NCBI_TaxID=402239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate ANT5.10, Isolate ANT5.12, Isolate ANT5.8, and
RC Isolate ANT5.9;
RA Andriantompohavana R., Lei R., Zaonarivelo J.R., Engberg S.E.,
RA Nalanirina G., McGuire S.M., Shore G.D., Andrianasolo J., Herrington K.,
RA Brenneman R.A., Louis E.E. Jr.;
RT "Molecular phylogeny and taxonomic revision of the woolly lemurs, genus
RT Avahi (primates: lemuriformes).";
RL Spec. Publ. Mus. Tex. Tech. Univ. 51:1-64(2007).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. {ECO:0000250|UniProtKB:P03902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03902}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; DQ856109; ABI54980.1; -; Genomic_DNA.
DR EMBL; DQ856110; ABI54984.1; -; Genomic_DNA.
DR EMBL; DQ856111; ABI54988.1; -; Genomic_DNA.
DR EMBL; DQ856112; ABI54992.1; -; Genomic_DNA.
DR AlphaFoldDB; A8DQI8; -.
DR SMR; A8DQI8; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..98
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000323387"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 98 AA; 10787 MW; 9950328789276605 CRC64;
MPPIFANIIL AFATAFLGTL IFRSHLMSSL LCLEGMMLSM FILSTLIILN MHLTVSFMMP
ILLLVFAACE AAIGLALLVM VSNTYGLDYI KNLNLLQC
