NU4LM_BALBO
ID NU4LM_BALBO Reviewed; 98 AA.
AC Q598Z5; Q69B68;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS Balaenoptera borealis (Sei whale) (Pollack whale).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=9768;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15288064; DOI=10.1016/j.ympev.2004.02.020;
RA Rychel A.L., Reeder T.W., Berta A.;
RT "Phylogeny of mysticete whales based on mitochondrial and nuclear data.";
RL Mol. Phylogenet. Evol. 32:892-901(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15805012; DOI=10.1080/10635150590905939;
RA Sasaki T., Nikaido M., Hamilton H., Goto M., Kato H., Kanda N.,
RA Pastene L.A., Cao Y., Fordyce R.E., Hasegawa M., Okada N.;
RT "Mitochondrial phylogenetics and evolution of mysticete whales.";
RL Syst. Biol. 54:77-90(2005).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. {ECO:0000250|UniProtKB:P03902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03902}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; AY398632; AAR33071.1; -; Genomic_DNA.
DR EMBL; AP006470; BAD91728.1; -; Genomic_DNA.
DR RefSeq; YP_220753.1; NC_006929.1.
DR AlphaFoldDB; Q598Z5; -.
DR SMR; Q598Z5; -.
DR GeneID; 3337159; -.
DR CTD; 4539; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..98
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000274978"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 14
FT /note="M -> V (in Ref. 1; AAR33071)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 98 AA; 10719 MW; 9D750653EE4F6FA1 CRC64;
MTLIHMNVLM AFSMSLVGLL MYRSHLMSAL LCLEGMMLSL FTLAALTILN SHFTLANMMP
IILLVFAACE AAIGLALLVM VSNTYGTDYV QSLNLLQC
