ID   NU4LM_BALMY             Reviewed;          98 AA.
AC   Q70S32;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS   Balaena mysticetus (Bowhead whale).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenidae; Balaena.
OX   NCBI_TaxID=27602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15177677; DOI=10.1016/j.gene.2004.02.010;
RA   Arnason U., Gullberg A., Janke A.;
RT   "Mitogenomic analyses provide new insights into cetacean origin and
RT   evolution.";
RL   Gene 333:27-34(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Z6985;
RX   PubMed=15288064; DOI=10.1016/j.ympev.2004.02.020;
RA   Rychel A.L., Reeder T.W., Berta A.;
RT   "Phylogeny of mysticete whales based on mitochondrial and nuclear data.";
RL   Mol. Phylogenet. Evol. 32:892-901(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15805012; DOI=10.1080/10635150590905939;
RA   Sasaki T., Nikaido M., Hamilton H., Goto M., Kato H., Kanda N.,
RA   Pastene L.A., Cao Y., Fordyce R.E., Hasegawa M., Okada N.;
RT   "Mitochondrial phylogenetics and evolution of mysticete whales.";
RL   Syst. Biol. 54:77-90(2005).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. {ECO:0000250|UniProtKB:P03902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03902}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR   EMBL; AJ554051; CAD87892.1; -; Genomic_DNA.
DR   EMBL; AY398630; AAR33067.1; -; Genomic_DNA.
DR   EMBL; AP006472; BAD91754.1; -; Genomic_DNA.
DR   RefSeq; NP_944615.1; NC_005268.1.
DR   AlphaFoldDB; Q70S32; -.
DR   SMR; Q70S32; -.
DR   GeneID; 2658543; -.
DR   CTD; 4539; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..98
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000274979"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   98 AA;  10730 MW;  041A3D3CAC1B88D7 CRC64;
     MTLTHMNIIM AFSMSLVGLL MYRSHLMSAL LCLEGMMLSL FVLAALTILN SHFTLANMMP
     IILLVFAACE AAIGLALLVT ISNTYGTDYV QNLNLLQC