NU4LM_CAEBR
ID NU4LM_CAEBR Reviewed; 77 AA.
AC Q8HEB9; B1PE34; B1PEQ0;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=nd4l;
OS Caenorhabditis briggsae.
OG Mitochondrion {ECO:0000312|EMBL:AAO13514.1}.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000312|EMBL:AAO13514.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=PB800;
RX PubMed=12644560; DOI=10.1093/molbev/msg044;
RA Denver D.R., Morris K., Thomas W.K.;
RT "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and
RT outcrossing.";
RL Mol. Biol. Evol. 20:393-400(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-62.
RC STRAIN=BW287, ED3032, ED3033, ED3034, ED3035, ED3036, ED3037, ED3083,
RC ED3092, ED3101, EG4181, EG4207A, HK104, HK105, JU403, JU439, JU516, JU725,
RC JU726, JU793, PB800, PB826, and VT847;
RX PubMed=18302772; DOI=10.1186/1471-2148-8-62;
RA Howe D.K., Denver D.R.;
RT "Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae
RT mitochondrial genome evolution.";
RL BMC Evol. Biol. 8:62-62(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO13514.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY171106; AAO13514.1; ALT_INIT; Genomic_DNA.
DR EMBL; EU407781; ACB06101.1; -; Genomic_DNA.
DR EMBL; EU407782; ACB06113.1; -; Genomic_DNA.
DR EMBL; EU407783; ACB06125.1; -; Genomic_DNA.
DR EMBL; EU407784; ACB06137.1; -; Genomic_DNA.
DR EMBL; EU407785; ACB06149.1; -; Genomic_DNA.
DR EMBL; EU407786; ACB06161.1; -; Genomic_DNA.
DR EMBL; EU407787; ACB06173.1; -; Genomic_DNA.
DR EMBL; EU407788; ACB06185.1; -; Genomic_DNA.
DR EMBL; EU407789; ACB06197.1; -; Genomic_DNA.
DR EMBL; EU407790; ACB06209.1; -; Genomic_DNA.
DR EMBL; EU407791; ACB06221.1; -; Genomic_DNA.
DR EMBL; EU407792; ACB06233.1; -; Genomic_DNA.
DR EMBL; EU407793; ACB06245.1; -; Genomic_DNA.
DR EMBL; EU407794; ACB06257.1; -; Genomic_DNA.
DR EMBL; EU407795; ACB06269.1; -; Genomic_DNA.
DR EMBL; EU407796; ACB06281.1; -; Genomic_DNA.
DR EMBL; EU407797; ACB06293.1; -; Genomic_DNA.
DR EMBL; EU407798; ACB06305.1; -; Genomic_DNA.
DR EMBL; EU407799; ACB06317.1; -; Genomic_DNA.
DR EMBL; EU407800; ACB06329.1; -; Genomic_DNA.
DR EMBL; EU407801; ACB06341.1; -; Genomic_DNA.
DR EMBL; EU407802; ACB06353.1; -; Genomic_DNA.
DR EMBL; EU407803; ACB06365.1; -; Genomic_DNA.
DR EMBL; AC186293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; YP_001504338.1; NC_009885.1.
DR AlphaFoldDB; Q8HEB9; -.
DR SMR; Q8HEB9; -.
DR GeneID; 5666630; -.
DR KEGG; cbr:ND4L; -.
DR CTD; 4539; -.
DR InParanoid; Q8HEB9; -.
DR Proteomes; UP000008549; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..77
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000118400"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 62
FT /note="V -> I (in strain: JU726)"
FT /evidence="ECO:0000269|PubMed:18302772"
SQ SEQUENCE 77 AA; 9275 MW; 92F02A3B0D6A7D56 CRC64;
MMFLFVSLFM FIFKWQRLIF ILISLEFLML SLFLKFSYLL SEMMFFYFMC FSVISSILGM
VVMVGNMKFF GSDNCIF
