NU4LM_CAEEL
ID NU4LM_CAEEL Reviewed; 77 AA.
AC P24886;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 11-APR-2003, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=ndfl-4 {ECO:0000312|WormBase:MTCE.4};
GN Synonyms=nd4l {ECO:0000312|WormBase:MTCE.4};
GN ORFNames=MTCE.4 {ECO:0000312|WormBase:MTCE.4};
OS Caenorhabditis elegans.
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-41 AND LEU-70.
RC STRAIN=AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856,
RC CB4857, CB4858, KR314, PB303, PB306, RW7000, and TR403;
RX PubMed=12644560; DOI=10.1093/molbev/msg044;
RA Denver D.R., Morris K., Thomas W.K.;
RT "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and
RT outcrossing.";
RL Mol. Biol. Evol. 20:393-400(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=1551572; DOI=10.1093/genetics/130.3.471;
RA Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.;
RT "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and
RT Ascaris suum.";
RL Genetics 130:471-498(1992).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; AY171133; AAO16386.1; -; Genomic_DNA.
DR EMBL; AY171134; AAO16389.1; -; Genomic_DNA.
DR EMBL; AY171135; AAO16392.1; -; Genomic_DNA.
DR EMBL; AY171136; AAO16395.1; -; Genomic_DNA.
DR EMBL; AY171137; AAO16398.1; -; Genomic_DNA.
DR EMBL; AY171138; AAO16401.1; -; Genomic_DNA.
DR EMBL; AY171139; AAO16404.1; -; Genomic_DNA.
DR EMBL; AY171140; AAO16407.1; -; Genomic_DNA.
DR EMBL; AY171141; AAO16410.1; -; Genomic_DNA.
DR EMBL; AY171142; AAO16413.1; -; Genomic_DNA.
DR EMBL; AY171143; AAO16416.1; -; Genomic_DNA.
DR EMBL; AY171144; AAO16419.1; -; Genomic_DNA.
DR EMBL; AY171145; AAO16422.1; -; Genomic_DNA.
DR EMBL; AY171146; AAO16425.1; -; Genomic_DNA.
DR EMBL; AY171147; AAO16428.1; -; Genomic_DNA.
DR EMBL; X54252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; S26027; S26027.
DR RefSeq; NP_006954.1; NC_001328.1.
DR AlphaFoldDB; P24886; -.
DR SMR; P24886; -.
DR STRING; 6239.MTCE.4; -.
DR EPD; P24886; -.
DR PaxDb; P24886; -.
DR GeneID; 2565694; -.
DR KEGG; cel:ND4L; -.
DR CTD; 4539; -.
DR WormBase; MTCE.4; CE35354; WBGene00010958; ndfl-4.
DR HOGENOM; CLU_2640347_0_0_1; -.
DR InParanoid; P24886; -.
DR PRO; PR:P24886; -.
DR Proteomes; UP000001940; Mitochondrion.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:WormBase.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..77
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000118401"
FT TRANSMEM 15..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 41
FT /note="G -> S (in strain: PB303)"
FT /evidence="ECO:0000269|PubMed:12644560"
FT VARIANT 70
FT /note="F -> L (in strain: CB4855)"
FT /evidence="ECO:0000269|PubMed:12644560"
SQ SEQUENCE 77 AA; 9249 MW; F123ECE07D07A829 CRC64;
MMFLFVSLFM FIFKWQRLIF ILISLEFMML SLFLKFSYVL GEMMFFYFMC FSVISSILGM
VVMVGNMKFF GSDNCIF
