ID   NU4LM_CANLF             Reviewed;          98 AA.
AC   Q9ZZ59;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000312|Proteomes:UP000002254};
RX   PubMed=9878232; DOI=10.1006/mpev.1998.0513;
RA   Kim K.S., Lee S.E., Jeong H.W., Ha J.H.;
RT   "The complete nucleotide sequence of the domestic dog (Canis familiaris)
RT   mitochondrial genome.";
RL   Mol. Phylogenet. Evol. 10:210-220(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Beagle;
RA   Zhu S., Xu Q., Chang H.;
RT   "The complete mitochondrial DNA sequence of the Beagle dog (Canis
RT   familiaris).";
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. {ECO:0000250|UniProtKB:P03902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03902}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR   EMBL; U96639; AAD04771.1; -; Genomic_DNA.
DR   EMBL; AY729880; AAU12155.1; -; Genomic_DNA.
DR   PIR; T11501; T11501.
DR   RefSeq; NP_008479.1; NC_002008.4.
DR   AlphaFoldDB; Q9ZZ59; -.
DR   SMR; Q9ZZ59; -.
DR   STRING; 9612.ENSCAFP00000030317; -.
DR   PaxDb; Q9ZZ59; -.
DR   GeneID; 804482; -.
DR   KEGG; cfa:804482; -.
DR   CTD; 4539; -.
DR   eggNOG; KOG4669; Eukaryota.
DR   HOGENOM; CLU_182394_0_0_1; -.
DR   InParanoid; Q9ZZ59; -.
DR   OMA; YRSHLMS; -.
DR   OrthoDB; 1538435at2759; -.
DR   TreeFam; TF338190; -.
DR   Proteomes; UP000002254; Mitochondrion.
DR   Bgee; ENSCAFG00000022734; Expressed in heart right ventricle and 47 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..98
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000118402"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   98 AA;  10862 MW;  63B13880B8B9E93E CRC64;
     MSMVYINIFL AFILSLMGML VYRSHLMSSL LCLEGMMLSL FVMMSVTILN NHLTLASMMP
     IVLLVFAACE AALGLSLLVM VSNTYGTDYV QNLNLLQC