ID   NU4LM_CAPHI             Reviewed;          98 AA.
AC   Q7YBC1; D0VEG2;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS   Capra hircus (Goat).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=De Co;
RX   PubMed=20540682; DOI=10.3109/19401736.2010.490583;
RA   Hassanin A., Bonillo C., Nguyen B.X., Cruaud C.;
RT   "Comparisons between mitochondrial genomes of domestic goat (Capra hircus)
RT   reveal the presence of numts and multiple sequencing errors.";
RL   Mitochondrial DNA 21:68-76(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Inner Mongolia White Cashmere;
RA   Xi W.H., Zhang W.G., Li J.Q., Wu J.H., Zhang Y.J., Feng L.;
RT   "Characterization of mitochondrial cyt b-like numt sequence in Inner
RT   Mongolia white cashmere goat.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A-MG25, B-LK31, and C-WZ37;
RA   Wu Y.P., Ma Y.H.;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. {ECO:0000250|UniProtKB:P03902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03902}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR   EMBL; GU295658; ADB07178.1; -; Genomic_DNA.
DR   EMBL; GU068049; ACY01505.1; -; Genomic_DNA.
DR   EMBL; GU229278; ACZ61138.1; -; Genomic_DNA.
DR   EMBL; GU229279; ACZ61151.1; -; Genomic_DNA.
DR   EMBL; GU229280; ACZ61164.1; -; Genomic_DNA.
DR   RefSeq; YP_004111304.1; NC_005044.2.
DR   AlphaFoldDB; Q7YBC1; -.
DR   SMR; Q7YBC1; -.
DR   STRING; 9925.ENSCHIP00000000009; -.
DR   Ensembl; ENSCHIT00000000027; ENSCHIP00000000009; ENSCHIG00000000027.
DR   GeneID; 1485864; -.
DR   KEGG; chx:1485864; -.
DR   CTD; 4539; -.
DR   GeneTree; ENSGT00390000004755; -.
DR   OMA; YRSHLMS; -.
DR   OrthoDB; 1538435at2759; -.
DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   Bgee; ENSCHIG00000000027; Expressed in prefrontal cortex and 17 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..98
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000274986"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   98 AA;  10795 MW;  A4C099E9FC2C1521 CRC64;
     MSLVYMNIMT AFAVSLTGLL MYRSHLMSSL LCLEGMMLSL FIMATLMILN SHFTLASMMP
     IILLVFAACE AALGLSLLVM VSNTYGTDYV QNLNLLQC