ID   NU4LM_CHOCR             Reviewed;         101 AA.
AC   P48930;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=ND4L; Synonyms=NAD4L;
OS   Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa).
OG   Mitochondrion.
OC   Eukaryota; Rhodophyta; Florideophyceae; Rhodymeniophycidae; Gigartinales;
OC   Gigartinaceae; Chondrus.
OX   NCBI_TaxID=2769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Apices;
RX   PubMed=7616569; DOI=10.1006/jmbi.1995.0392;
RA   Leblanc C., Boyen C., Richard O., Bonnard G., Grienenberger J.-M.,
RA   Kloareg B.;
RT   "Complete sequence of the mitochondrial DNA of the rhodophyte Chondrus
RT   crispus (Gigartinales). Gene content and genome organization.";
RL   J. Mol. Biol. 250:484-495(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Apices;
RX   PubMed=7666449; DOI=10.1007/bf00170673;
RA   Leblanc C., Kloareg B., Loiseaux-De Goer S., Boyen C.;
RT   "DNA sequence, structure, and phylogenetic relationship of the
RT   mitochondrial small-subunit rRNA from the red alga Chondrus crispus
RT   (Gigartinales rhodophytes).";
RL   J. Mol. Evol. 41:196-202(1995).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z47547; CAA87597.1; -; Genomic_DNA.
DR   EMBL; Z30950; CAA83211.1; -; Genomic_DNA.
DR   PIR; S59081; S59081.
DR   RefSeq; NP_062504.1; NC_001677.2.
DR   AlphaFoldDB; P48930; -.
DR   SMR; P48930; -.
DR   GeneID; 809403; -.
DR   KEGG; ccp:ChcroMp25; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   HAMAP; MF_01456; NDH1_NuoK; 1.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..101
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000118408"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   101 AA;  11354 MW;  F069DF0CC34B6531 CRC64;
     MFQQLNCTNI SSLLFLVSLL GIFLNQKNIL VMLMSLEMMF LSISFNLIFS SIRLDDIIGQ
     IFSLLILTVA AAESSIGLAI LVIYYRIRST ITVELMNLMK G