ID   NU4LM_DANRE             Reviewed;          98 AA.
AC   Q9MIY2;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=mt-nd4l; Synonyms=mtnd4l, nd4l;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000312|Proteomes:UP000000437};
RX   PubMed=11691861; DOI=10.1101/gr.156801;
RA   Broughton R.E., Milam J.E., Roe B.A.;
RT   "The complete sequence of the zebrafish (Danio rerio) mitochondrial genome
RT   and evolutionary patterns in vertebrate mitochondrial DNA.";
RL   Genome Res. 11:1958-1967(2001).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. {ECO:0000250|UniProtKB:P03902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03902}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR   EMBL; AC024175; AAF74305.1; -; Genomic_DNA.
DR   RefSeq; NP_059339.1; NC_002333.2.
DR   AlphaFoldDB; Q9MIY2; -.
DR   SMR; Q9MIY2; -.
DR   STRING; 7955.ENSDARP00000087877; -.
DR   PaxDb; Q9MIY2; -.
DR   Ensembl; ENSDART00000093617; ENSDARP00000087877; ENSDARG00000063916.
DR   GeneID; 140538; -.
DR   KEGG; dre:140538; -.
DR   CTD; 4539; -.
DR   ZFIN; ZDB-GENE-011205-11; mt-nd4l.
DR   eggNOG; KOG4669; Eukaryota.
DR   GeneTree; ENSGT00940000164968; -.
DR   HOGENOM; CLU_182394_0_0_1; -.
DR   InParanoid; Q9MIY2; -.
DR   OMA; YRSHLMS; -.
DR   OrthoDB; 1538435at2759; -.
DR   PhylomeDB; Q9MIY2; -.
DR   TreeFam; TF338190; -.
DR   PRO; PR:Q9MIY2; -.
DR   Proteomes; UP000000437; Mitochondrion MT.
DR   Proteomes; UP000814640; Mitochondrion.
DR   Bgee; ENSDARG00000063916; Expressed in early embryo and 20 other tissues.
DR   ExpressionAtlas; Q9MIY2; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..98
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000118399"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   98 AA;  10524 MW;  54C4B6230D23EF24 CRC64;
     MTPTHFSLNA AFMLGLAGLT FHRVHLLSAL LCLEGMMLSL FISMALWTLK TESMSLSTAP
     MLLLAFSACE ASAGLALLVA TARTHGSDHM KNLNLLQC