NU4LM_DROME
ID NU4LM_DROME Reviewed; 96 AA.
AC P18934; Q7HM98;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=mt:ND4L; Synonyms=ND4L;
OS Drosophila melanogaster (Fruit fly).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bretagne;
RX PubMed=3130291; DOI=10.1093/genetics/118.4.649;
RA Garesse R.;
RT "Drosophila melanogaster mitochondrial DNA: gene organization and
RT evolutionary considerations.";
RL Genetics 118:649-663(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Oregon-R, and Zimbabwe 53;
RX PubMed=10903372; DOI=10.1007/s002390010066;
RA Ballard J.W.O.;
RT "Comparative genomics of mitochondrial DNA in members of the Drosophila
RT melanogaster subgroup.";
RL J. Mol. Evol. 51:48-63(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Paris;
RX PubMed=11298822; DOI=10.1046/j.1365-2540.2001.00814.x;
RA Azou Y., Bregliano J.C.;
RT "I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of
RT the mitochondrial DNA in reactive strains exhibiting different potentials
RT for I factor transposition.";
RL Heredity 86:110-116(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8825764; DOI=10.1111/j.1365-2583.1995.tb00032.x;
RA Lewis D.L., Farr C.L., Kaguni L.S.;
RT "Drosophila melanogaster mitochondrial DNA: completion of the nucleotide
RT sequence and evolutionary comparisons.";
RL Insect Mol. Biol. 4:263-278(1995).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RA Wan K., Celniker S.;
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; M37275; AAA69712.1; -; Genomic_DNA.
DR EMBL; AF200828; AAF77235.1; -; Genomic_DNA.
DR EMBL; AF200829; AAF77247.1; -; Genomic_DNA.
DR EMBL; AJ400907; CAB91060.1; -; Genomic_DNA.
DR EMBL; U37541; AAC47820.1; -; Genomic_DNA.
DR EMBL; KJ947872; AIC64013.1; -; Genomic_DNA.
DR PIR; S01188; S01188.
DR RefSeq; YP_009047275.1; NC_024511.2.
DR AlphaFoldDB; P18934; -.
DR SMR; P18934; -.
DR STRING; 7227.FBpp0100184; -.
DR PaxDb; P18934; -.
DR EnsemblMetazoa; FBtr0100880; FBpp0100184; FBgn0013683.
DR GeneID; 19893552; -.
DR KEGG; dme:Dmel_CG34086; -.
DR CTD; 4539; -.
DR FlyBase; FBgn0013683; mt:ND4L.
DR VEuPathDB; VectorBase:FBgn0013683; -.
DR eggNOG; KOG4669; Eukaryota.
DR HOGENOM; CLU_182394_0_0_1; -.
DR InParanoid; P18934; -.
DR OMA; YINIMLA; -.
DR OrthoDB; 1538435at2759; -.
DR PhylomeDB; P18934; -.
DR BioGRID-ORCS; 19893552; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 19893552; -.
DR PRO; PR:P18934; -.
DR Proteomes; UP000000803; Mitochondrion.
DR Bgee; FBgn0013683; Expressed in Malpighian tubule and 17 other tissues.
DR ExpressionAtlas; P18934; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..96
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000118417"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 96 AA; 11359 MW; D383557D738A175B CRC64;
MIMILYWSLP MILFILGLFC FVSNRKHLLS MLLSLEFIVL MLFFMLFIYL NMLNYESYFS
MMFLTFSVCE GALGLSILVS MIRTHGNDYF QSFSIM
