ID   NU4LM_LEMCA             Reviewed;          98 AA.
AC   Q94Y87;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS   Lemur catta (Ring-tailed lemur).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Lemuridae; Lemur.
OX   NCBI_TaxID=9447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate JP3;
RX   PubMed=12393004; DOI=10.1016/s0047-2484(02)90587-7;
RA   Pastorini J., Forstner M.R., Martin R.D.;
RT   "Phylogenetic relationships among Lemuridae (Primates): evidence from
RT   mtDNA.";
RL   J. Hum. Evol. 43:463-478(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate JP3, and Isolate JP52;
RX   PubMed=12719521; DOI=10.1073/pnas.1031673100;
RA   Pastorini J., Thalmann U., Martin R.D.;
RT   "A molecular approach to comparative phylogeography of extant Malagasy
RT   lemurs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:5879-5884(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12034869; DOI=10.1073/pnas.102164299;
RA   Arnason U., Adegoke J.A., Bodin K., Born E.W., Esa Y.B., Gullberg A.,
RA   Nilsson M., Short R.V., Xu X., Janke A.;
RT   "Mammalian mitogenomic relationships and the root of the eutherian tree.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:8151-8156(2002).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. {ECO:0000250|UniProtKB:P03902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03902}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR   EMBL; AF053684; AAL18018.1; -; Genomic_DNA.
DR   EMBL; AF224569; AAN64755.1; -; Genomic_DNA.
DR   EMBL; AF224570; AAN64759.1; -; Genomic_DNA.
DR   EMBL; AJ421451; CAD13429.1; -; Genomic_DNA.
DR   RefSeq; NP_659296.1; NC_004025.1.
DR   AlphaFoldDB; Q94Y87; -.
DR   SMR; Q94Y87; -.
DR   GeneID; 804966; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..98
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000118435"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   98 AA;  10720 MW;  2FD8BA799143298C CRC64;
     MPSISTNIIL AFITALLGML IFRSHLMSSL LCLEGMMLSM FILSTLTILS LHFTTSFMMP
     ILLLVFAACE AAVGLALLVT VSNTYGLDYI QNLNLLQC