ID   NU4LM_LOXAF             Reviewed;          98 AA.
AC   Q9TA21; Q2I3F3;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS   Loxodonta africana (African elephant).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Blood;
RA   Hauf J., Waddell P.J., Chalwatzis N., Joger U., Zimmermann F.K.;
RT   "The complete mitochondrial genome sequence of the African elephant
RT   (Loxodonta africana), phylogenetic relationships of Proboscidea to other
RT   mammals and D-loop heteroplasmy.";
RL   Zoology 102:184-195(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Blood;
RX   PubMed=16448217; DOI=10.1371/journal.pbio.0040073;
RA   Rogaev E.I., Moliaka Y.K., Malyarchuk B.A., Kondrashov F.A., Derenko M.V.,
RA   Chumakov I., Grigorenko A.P.;
RT   "Complete mitochondrial genome and phylogeny of Pleistocene mammoth
RT   Mammuthus primigenius.";
RL   PLoS Biol. 4:403-410(2006).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. {ECO:0000250|UniProtKB:P03902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03902}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR   EMBL; AJ224821; CAA12146.1; -; Genomic_DNA.
DR   EMBL; DQ316069; ABC17912.1; -; Genomic_DNA.
DR   PIR; T45558; T45558.
DR   RefSeq; NP_009287.1; NC_000934.1.
DR   AlphaFoldDB; Q9TA21; -.
DR   SMR; Q9TA21; -.
DR   STRING; 9785.ENSLAFP00000029499; -.
DR   Ensembl; ENSLAFT00000038061; ENSLAFP00000029499; ENSLAFG00000033295.
DR   GeneID; 808785; -.
DR   KEGG; lav:808785; -.
DR   CTD; 4539; -.
DR   eggNOG; KOG4669; Eukaryota.
DR   GeneTree; ENSGT00390000004755; -.
DR   HOGENOM; CLU_182394_0_0_1; -.
DR   InParanoid; Q9TA21; -.
DR   OMA; YRSHLMS; -.
DR   OrthoDB; 1538435at2759; -.
DR   TreeFam; TF338190; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..98
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000118437"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   98 AA;  10817 MW;  E94096B80BB85400 CRC64;
     MPYIYMNITL AFVISLIGTL MYRSHLMSSL LCLEGMMLSL FTLNALLSLN MNFTLSTTVP
     LILLVFAACE AAVGLALLVM ISNTYGLDYV QNLNLLQC