ID   NU4LM_MACMU             Reviewed;          98 AA.
AC   Q6IYH0;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS   Macaca mulatta (Rhesus macaque).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000312|Proteomes:UP000006718};
RX   PubMed=15379855; DOI=10.1111/j.1474-9728.2004.00122.x;
RA   Gokey N.G., Cao Z., Pak J.W., Lee D., McKiernan S.H., McKenzie D.,
RA   Weindruch R., Aiken J.M.;
RT   "Molecular analyses of mtDNA deletion mutations in microdissected skeletal
RT   muscle fibers from aged rhesus monkeys.";
RL   Aging Cell 3:319-326(2004).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. {ECO:0000250|UniProtKB:P03902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03902}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR   EMBL; AY612638; AAT11994.1; -; Genomic_DNA.
DR   RefSeq; YP_026112.1; NC_005943.1.
DR   AlphaFoldDB; Q6IYH0; -.
DR   SMR; Q6IYH0; -.
DR   STRING; 9544.ENSMMUP00000031376; -.
DR   Ensembl; ENSMMUT00000110395; ENSMMUP00000081251; ENSMMUG00000065379.
DR   GeneID; 2846621; -.
DR   KEGG; mcc:2846621; -.
DR   CTD; 4539; -.
DR   VEuPathDB; HostDB:ENSMMUG00000065379; -.
DR   eggNOG; KOG4669; Eukaryota.
DR   GeneTree; ENSGT00390000004755; -.
DR   HOGENOM; CLU_182394_0_0_1; -.
DR   InParanoid; Q6IYH0; -.
DR   OMA; YRSHLMS; -.
DR   OrthoDB; 1538435at2759; -.
DR   TreeFam; TF338190; -.
DR   Proteomes; UP000006718; Mitochondrion.
DR   Bgee; ENSMMUG00000065379; Expressed in fibroblast and 18 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..98
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000275048"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   98 AA;  10787 MW;  E60D98D7FC8C8B80 CRC64;
     MTLTYMNIML AFAISLLGML TYRSHLVASL LCLEGMMMSL FIMATLIASN THFPLINIMP
     IILLVFAACE TAVGLALLIS ISNTYGLDYV HNLNLLQC