NU4LM_MICMM
ID NU4LM_MICMM Reviewed; 98 AA.
AC Q00GF0; Q00GF8;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS Microcebus mamiratra (Claire's mouse lemur).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Cheirogaleidae; Microcebus.
OX NCBI_TaxID=415757;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate LOKO4.26, Isolate LOKO4.37, Isolate LOKO4.38, and
RC Isolate PBZT130;
RA Andriantompohavana R., Zaonarivelo J.R., Engberg S.E.,
RA Randriamampionona R., McGuire S.M., Shore G.D., Rakotonomenjanahary R.,
RA Brenneman R.A., Louis E.E. Jr.;
RT "Mouse lemurs of Northwestern Madagascar with a description of a new
RT species at Lokobe Special Reserve.";
RL (In) Baker R.J. (eds.);
RL Occasional Papers of the Texas Tech University Museum, pp.259:1-24, Texas
RL Tech University, Lubbock (2006).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. {ECO:0000250|UniProtKB:P03902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03902}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; DQ535017; ABG02113.1; -; Genomic_DNA.
DR EMBL; DQ535018; ABG02117.1; -; Genomic_DNA.
DR EMBL; DQ535019; ABG02121.1; -; Genomic_DNA.
DR EMBL; DQ535020; ABG02125.1; -; Genomic_DNA.
DR AlphaFoldDB; Q00GF0; -.
DR SMR; Q00GF0; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..98
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000275058"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 60
FT /note="P -> R (in strain: Isolate LOKO4.37)"
SQ SEQUENCE 98 AA; 10708 MW; B86F70ABC642F961 CRC64;
MPSISININL AFAAALLGML MFRSHMMSSL LCLEGMMLSM FTLSTLIILN LQLTMSFTMP
ILLLVFAACE AAIGLALLVT VSNNYGLDYI QNLNLLQC
