ID   NU4LM_MICRA             Reviewed;          98 AA.
AC   Q94Q33;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS   Microcebus ravelobensis (Golden-brown mouse lemur).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Cheirogaleidae; Microcebus.
OX   NCBI_TaxID=122231;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12719521; DOI=10.1073/pnas.1031673100;
RA   Pastorini J., Thalmann U., Martin R.D.;
RT   "A molecular approach to comparative phylogeography of extant Malagasy
RT   lemurs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:5879-5884(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate ANK18, Isolate ANK24, Isolate ANK25, Isolate ANK7, and
RC   Isolate ANK9;
RA   Louis E.E. Jr., Coles M.S., Andriantompohavana R., Sommer J.A.,
RA   Engberg S.E., Zaonarivelo J.R., Mayor M.I., Brenneman R.A.;
RT   "Revision of the mouse lemurs (Microcebus) of Eastern Madagascar.";
RL   Int. J. Primatol. 27:347-389(2006).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. {ECO:0000250|UniProtKB:P03902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03902}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR   EMBL; AF224630; AAK70573.1; -; Genomic_DNA.
DR   EMBL; AF224631; AAK70577.1; -; Genomic_DNA.
DR   EMBL; AF224632; AAK70581.1; -; Genomic_DNA.
DR   EMBL; AF224633; AAK70585.1; -; Genomic_DNA.
DR   EMBL; AY582545; AAT35844.1; -; Genomic_DNA.
DR   EMBL; AY582632; AAS92719.1; -; Genomic_DNA.
DR   EMBL; AY582633; AAS92723.1; -; Genomic_DNA.
DR   EMBL; AY582634; AAS92727.1; -; Genomic_DNA.
DR   EMBL; AY582635; AAS92731.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q94Q33; -.
DR   SMR; Q94Q33; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..98
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000275059"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   98 AA;  10818 MW;  199D5F343F1B8582 CRC64;
     MLSISININL AFAAALLGML MFRSHMMSSL LCLEGMMLSM FILSTLIILN MQFTMSFTMP
     ILLLVFAACE AAIGLALLVM VSNNYGLDYI QNLNLLQC