NU4LM_MICSI
ID NU4LM_MICSI Reviewed; 98 AA.
AC Q591M6;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS Microcebus simmonsi (Simmons's mouse lemur).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Cheirogaleidae; Microcebus.
OX NCBI_TaxID=236272;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate BET29, Isolate BET35, Isolate BET39, Isolate BET87,
RC Isolate PBZT117, Isolate ZAH12, Isolate ZAH2, Isolate ZAH5, and
RC Isolate ZAH7;
RA Louis E.E. Jr., Coles M.S., Andriantompohavana R., Sommer J.A.,
RA Engberg S.E., Zaonarivelo J.R., Mayor M.I., Brenneman R.A.;
RT "Revision of the mouse lemurs (Microcebus) of Eastern Madagascar.";
RL Int. J. Primatol. 27:347-389(2006).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. {ECO:0000250|UniProtKB:P03902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03902}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; AY582663; AAS92843.1; -; Genomic_DNA.
DR EMBL; AY582664; AAS92847.1; -; Genomic_DNA.
DR EMBL; AY582665; AAS92851.1; -; Genomic_DNA.
DR EMBL; AY582666; AAS92855.1; -; Genomic_DNA.
DR EMBL; AY582667; AAS92859.1; -; Genomic_DNA.
DR EMBL; AY582668; AAS92863.1; -; Genomic_DNA.
DR EMBL; AY582669; AAS92867.1; -; Genomic_DNA.
DR EMBL; AY582670; AAS92871.1; -; Genomic_DNA.
DR EMBL; AY582671; AAS92875.1; -; Genomic_DNA.
DR AlphaFoldDB; Q591M6; -.
DR SMR; Q591M6; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..98
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000275060"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 98 AA; 10820 MW; 1DDD4B65B68B1959 CRC64;
MPSISININL AFATALLGML MFRSHMMSSL LCLEGMMLSM FILSTLTILN MQFTMSFTMP
ILLLVFAACE AAIGLALLVM VSNNYGLDYI QNLNLLQC
