NU4LM_MONDO
ID NU4LM_MONDO Reviewed; 98 AA.
AC Q65CI5;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS Monodelphis domestica (Gray short-tailed opossum).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15008398; DOI=10.1007/s00239-003-0001-8;
RA Nilsson M.A., Gullberg A., Spotorno A.E., Arnason U., Janke A.;
RT "Radiation of extant marsupials after the K/T boundary: evidence from
RT complete mitochondrial genomes.";
RL J. Mol. Evol. 57:S3-S12(2003).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. {ECO:0000250|UniProtKB:P03902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03902}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; AJ508398; CAD48208.1; -; Genomic_DNA.
DR RefSeq; YP_087187.1; NC_006299.1.
DR AlphaFoldDB; Q65CI5; -.
DR SMR; Q65CI5; -.
DR STRING; 13616.ENSMODP00000026939; -.
DR Ensembl; ENSMODT00000027438; ENSMODP00000026939; ENSMODG00000021583.
DR GeneID; 3074657; -.
DR KEGG; mdo:3074657; -.
DR CTD; 4539; -.
DR eggNOG; KOG4669; Eukaryota.
DR GeneTree; ENSGT00390000004755; -.
DR HOGENOM; CLU_182394_0_0_1; -.
DR InParanoid; Q65CI5; -.
DR OMA; YRSHLMS; -.
DR OrthoDB; 1538435at2759; -.
DR TreeFam; TF338190; -.
DR Proteomes; UP000002280; Mitochondrion.
DR Bgee; ENSMODG00000021583; Expressed in skeletal muscle tissue and 21 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..98
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000275066"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 98 AA; 10794 MW; 15FE3274725A31D4 CRC64;
MEQINLNMIT AFTIALMGVL TYRSHLMSTL LCLEGMMLSL FILMVLLISH SHMVSMSMAP
LILLVFSACE AGVGLALLVT ISHTYGNDYV QNLNLLQC
