NU4LM_MOUSE
ID NU4LM_MOUSE Reviewed; 98 AA.
AC P03903;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-2015, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=Mtnd4l; Synonyms=mt-Nd4l, Nd4l;
OS Mus musculus (Mouse).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7332926; DOI=10.1016/0092-8674(81)90300-7;
RA Bibb M.J., van Etten R.A., Wright C.T., Walberg M.W., Clayton D.A.;
RT "Sequence and gene organization of mouse mitochondrial DNA.";
RL Cell 26:167-180(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=12954771; DOI=10.1093/nar/gkg739;
RA Bayona-Bafaluy M.P., Acin-Perez R., Mullikin J.C., Park J.S.,
RA Moreno-Loshuertos R., Hu P., Perez-Martos A., Fernandez-Silva P., Bai Y.,
RA Enriquez J.A.;
RT "Revisiting the mouse mitochondrial DNA sequence.";
RL Nucleic Acids Res. 31:5349-5355(2003).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. {ECO:0000250|UniProtKB:P03902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03902}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; J01420; AAB48652.1; -; Genomic_DNA.
DR EMBL; V00711; CAA24087.1; -; Genomic_DNA.
DR EMBL; AY172335; AAN85130.1; -; Genomic_DNA.
DR PIR; A00430; QXMS4L.
DR RefSeq; NP_904336.1; NC_005089.1.
DR PDB; 6G2J; EM; 3.30 A; K=1-98.
DR PDB; 6G72; EM; 3.90 A; K=1-98.
DR PDB; 6ZR2; EM; 3.10 A; K=1-98.
DR PDB; 6ZTQ; EM; 3.00 A; K=1-98.
DR PDB; 7AK5; EM; 3.17 A; K=1-98.
DR PDB; 7AK6; EM; 3.82 A; K=1-98.
DR PDB; 7B93; EM; 3.04 A; K=1-98.
DR PDB; 7PSA; EM; 3.40 A; K=1-98.
DR PDBsum; 6G2J; -.
DR PDBsum; 6G72; -.
DR PDBsum; 6ZR2; -.
DR PDBsum; 6ZTQ; -.
DR PDBsum; 7AK5; -.
DR PDBsum; 7AK6; -.
DR PDBsum; 7B93; -.
DR PDBsum; 7PSA; -.
DR AlphaFoldDB; P03903; -.
DR SMR; P03903; -.
DR ComplexPortal; CPX-266; Mitochondrial respiratory chain complex I.
DR IntAct; P03903; 1.
DR STRING; 10090.ENSMUSP00000081021; -.
DR iPTMnet; P03903; -.
DR SwissPalm; P03903; -.
DR PaxDb; P03903; -.
DR PRIDE; P03903; -.
DR ProteomicsDB; 289947; -.
DR Antibodypedia; 68604; 75 antibodies from 19 providers.
DR Ensembl; ENSMUST00000084013; ENSMUSP00000081021; ENSMUSG00000065947.
DR GeneID; 17720; -.
DR KEGG; mmu:17720; -.
DR CTD; 4539; -.
DR MGI; MGI:102497; mt-Nd4l.
DR VEuPathDB; HostDB:ENSMUSG00000065947; -.
DR eggNOG; KOG4669; Eukaryota.
DR GeneTree; ENSGT00390000004755; -.
DR HOGENOM; CLU_182394_0_0_1; -.
DR InParanoid; P03903; -.
DR OMA; YRSHLMS; -.
DR OrthoDB; 1538435at2759; -.
DR PhylomeDB; P03903; -.
DR ChiTaRS; mt-Nd4l; mouse.
DR PRO; PR:P03903; -.
DR Proteomes; UP000000589; Mitochondrion.
DR RNAct; P03903; protein.
DR Bgee; ENSMUSG00000065947; Expressed in cerebellar cortex and 60 other tissues.
DR ExpressionAtlas; P03903; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR GO; GO:0009060; P:aerobic respiration; IC:ComplexPortal.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR GO; GO:0042776; P:proton motive force-driven mitochondrial ATP synthesis; IC:ComplexPortal.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..98
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000118448"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 63
FT /note="Missing (in Ref. 1; AAB48652/CAA24087)"
FT /evidence="ECO:0000305"
FT HELIX 2..20
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT STRAND 24..26
FT /evidence="ECO:0007829|PDB:7B93"
FT HELIX 27..51
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT HELIX 54..56
FT /evidence="ECO:0007829|PDB:6ZR2"
FT HELIX 58..85
FT /evidence="ECO:0007829|PDB:6ZTQ"
FT STRAND 90..92
FT /evidence="ECO:0007829|PDB:6ZTQ"
SQ SEQUENCE 98 AA; 10607 MW; 48CAF698FF5F4C29 CRC64;
MPSTFFNLTM AFSLSLLGTL MFRSHLMSTL LCLEGMVLSL FIMTSVTSLN SNSMSSMPIP
ITILVFAACE AAVGLALLVK VSNTYGTDYV QNLNLLQC
