ID   NU4LM_ONCMY             Reviewed;          98 AA.
AC   P69302; P11630;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=8587139; DOI=10.1007/bf00173174;
RA   Zardoya R., Garrido-Pertierra A., Bautista J.M.;
RT   "The complete nucleotide sequence of the mitochondrial DNA genome of the
RT   rainbow trout, Oncorhynchus mykiss.";
RL   J. Mol. Evol. 41:942-951(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-92.
RX   PubMed=2550657; DOI=10.1007/bf02100207;
RA   Thomas W.K., Beckenbach A.T.;
RT   "Variation in salmonid mitochondrial DNA: evolutionary constraints and
RT   mechanisms of substitution.";
RL   J. Mol. Evol. 29:233-245(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
RC   TISSUE=Liver;
RX   PubMed=3265651; DOI=10.1007/bf00521273;
RA   Davidson W.S., Bartlett S.E., Birt T.P., Green J.M.;
RT   "Cloning and sequence analysis of an XbaI fragment of rainbow trout
RT   mitochondrial DNA.";
RL   Curr. Genet. 14:483-486(1988).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR   EMBL; L29771; AAB03355.1; -; Genomic_DNA.
DR   EMBL; X14013; CAA32179.1; -; Genomic_DNA.
DR   PIR; T09865; T09865.
DR   RefSeq; NP_008298.1; NC_001717.1.
DR   AlphaFoldDB; P69302; -.
DR   SMR; P69302; -.
DR   GeneID; 807974; -.
DR   KEGG; omy:807974; -.
DR   CTD; 4539; -.
DR   OrthoDB; 1538435at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..98
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000118459"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        3..7
FT                   /note="PVHFS -> ALWHQYTSA (in Ref. 3; CAA32179)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        26..27
FT                   /note="LL -> FS (in Ref. 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        29
FT                   /note="A -> P (in Ref. 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   98 AA;  10515 MW;  47D5F0494679A4D4 CRC64;
     MTPVHFSFTS AFILGLMGLA FHRTHLLSAL LCLEGMMLSL FIALSLWALQ MEATGYSVAP
     MLLLAFSACE ASAGLALLVA TARTHGTDRL QSLNLLQC