NU4LM_PIG
ID NU4LM_PIG Reviewed; 98 AA.
AC P56632;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS Sus scrofa (Pig).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9732457; DOI=10.1007/pl00006388;
RA Ursing B.M., Arnason U.;
RT "The complete mitochondrial DNA sequence of the pig (Sus scrofa).";
RL J. Mol. Evol. 47:302-306(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Landrace;
RX PubMed=10433971; DOI=10.1016/s0378-1119(99)00247-4;
RA Lin C.S., Sun Y.L., Liu C.Y., Yang P.C., Chang L.C., Cheng I.C.,
RA Mao S.J.T., Huang M.C.;
RT "Complete nucleotide sequence of pig (Sus scrofa) mitochondrial genome and
RT dating evolutionary divergence within artiodactyla.";
RL Gene 236:107-114(1999).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. {ECO:0000250|UniProtKB:P03902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03902}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; AJ002189; CAA05240.1; -; Genomic_DNA.
DR EMBL; AF034253; AAD34193.1; -; Genomic_DNA.
DR PIR; T10980; T10980.
DR RefSeq; NP_008642.1; NC_000845.1.
DR PDB; 5GPN; EM; 5.40 A; i=1-98.
DR PDB; 5GUP; EM; 4.00 A; k=1-98.
DR PDB; 7V2C; EM; 2.90 A; k=1-98.
DR PDB; 7V2D; EM; 3.30 A; k=1-98.
DR PDB; 7V2E; EM; 2.80 A; k=1-98.
DR PDB; 7V2F; EM; 3.10 A; k=1-98.
DR PDB; 7V2H; EM; 2.50 A; k=1-98.
DR PDB; 7V2K; EM; 2.70 A; k=1-98.
DR PDB; 7V2R; EM; 2.60 A; k=1-98.
DR PDB; 7V30; EM; 2.70 A; k=1-98.
DR PDB; 7V31; EM; 2.90 A; k=1-98.
DR PDB; 7V32; EM; 3.20 A; k=1-98.
DR PDB; 7V33; EM; 2.60 A; k=1-98.
DR PDB; 7V3M; EM; 2.90 A; k=1-98.
DR PDB; 7VBL; EM; 2.60 A; k=1-98.
DR PDB; 7VBP; EM; 2.80 A; k=1-98.
DR PDB; 7VC0; EM; 2.60 A; k=1-98.
DR PDB; 7VWL; EM; 2.70 A; k=1-98.
DR PDBsum; 5GPN; -.
DR PDBsum; 5GUP; -.
DR PDBsum; 7V2C; -.
DR PDBsum; 7V2D; -.
DR PDBsum; 7V2E; -.
DR PDBsum; 7V2F; -.
DR PDBsum; 7V2H; -.
DR PDBsum; 7V2K; -.
DR PDBsum; 7V2R; -.
DR PDBsum; 7V30; -.
DR PDBsum; 7V31; -.
DR PDBsum; 7V32; -.
DR PDBsum; 7V33; -.
DR PDBsum; 7V3M; -.
DR PDBsum; 7VBL; -.
DR PDBsum; 7VBP; -.
DR PDBsum; 7VC0; -.
DR PDBsum; 7VWL; -.
DR AlphaFoldDB; P56632; -.
DR SMR; P56632; -.
DR STRING; 9823.ENSSSCP00000019143; -.
DR PaxDb; P56632; -.
DR Ensembl; ENSSSCT00000019681; ENSSSCP00000019143; ENSSSCG00000018086.
DR Ensembl; ENSSSCT00070061683; ENSSSCP00070052586; ENSSSCG00070030646.
DR GeneID; 808509; -.
DR KEGG; ssc:808509; -.
DR CTD; 4539; -.
DR eggNOG; KOG4669; Eukaryota.
DR GeneTree; ENSGT00390000004755; -.
DR InParanoid; P56632; -.
DR OMA; YRSHLMS; -.
DR OrthoDB; 1538435at2759; -.
DR ChiTaRS; ND4L; pig.
DR Proteomes; UP000008227; Mitochondrion.
DR Proteomes; UP000314985; Mitochondrion.
DR Bgee; ENSSSCG00000018086; Expressed in Ammon's horn and 45 other tissues.
DR ExpressionAtlas; P56632; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..98
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000118473"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 98 AA; 10824 MW; 828C7F511A4E3AFA CRC64;
MPLVYMNIIM AFAIALAGLL MYRSHLMSSL LCLEGMMLSL FIMSTLIILN THFTLANMMP
IILLVFAACE AALGLSLLVM VSNTYGTDYV QNLNLLQC
