NU4LM_SHEEP
ID NU4LM_SHEEP Reviewed; 98 AA.
AC O78754;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS Ovis aries (Sheep).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Merinolandschaf {ECO:0000312|Proteomes:UP000002356}; TISSUE=Liver;
RX PubMed=9767689; DOI=10.1007/pl00006401;
RA Hiendleder S., Lewalski H., Wassmuth R., Janke A.;
RT "The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries)
RT and comparison with the other major ovine haplotype.";
RL J. Mol. Evol. 47:441-448(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. {ECO:0000250|UniProtKB:P03902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03902}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; AF010406; AAD10103.1; -; Genomic_DNA.
DR PIR; T11058; T11058.
DR RefSeq; NP_008414.1; NC_001941.1.
DR PDB; 5LNK; EM; 3.90 A; K=1-98.
DR PDB; 6Q9B; EM; 3.90 A; 4L=1-98.
DR PDB; 6QA9; EM; 4.10 A; 4L=1-98.
DR PDB; 6QBX; EM; 4.20 A; 4L=1-98.
DR PDB; 6QC2; EM; 4.20 A; 4L=1-98.
DR PDB; 6QC3; EM; 4.20 A; 4L=1-98.
DR PDB; 6QC4; EM; 4.60 A; 4L=1-98.
DR PDB; 6QC5; EM; 4.30 A; 4L=1-98.
DR PDB; 6QC6; EM; 4.10 A; 4L=1-98.
DR PDB; 6QC7; EM; 4.40 A; 4L=1-98.
DR PDB; 6QC8; EM; 4.20 A; 4L=1-98.
DR PDB; 6QC9; EM; 5.70 A; 4L=1-98.
DR PDB; 6QCA; EM; 6.20 A; 4L=1-98.
DR PDB; 6QCF; EM; 6.50 A; 4L=1-98.
DR PDB; 6ZKA; EM; 2.50 A; K=1-98.
DR PDB; 6ZKB; EM; 2.90 A; K=1-98.
DR PDB; 6ZKC; EM; 3.10 A; K=1-98.
DR PDB; 6ZKD; EM; 2.70 A; K=1-98.
DR PDB; 6ZKE; EM; 2.60 A; K=1-98.
DR PDB; 6ZKF; EM; 2.80 A; K=1-98.
DR PDB; 6ZKG; EM; 3.40 A; K=1-98.
DR PDB; 6ZKH; EM; 3.00 A; K=1-98.
DR PDB; 6ZKI; EM; 2.80 A; K=1-98.
DR PDB; 6ZKJ; EM; 3.00 A; K=1-98.
DR PDB; 6ZKK; EM; 3.70 A; K=1-98.
DR PDB; 6ZKL; EM; 3.10 A; K=1-98.
DR PDB; 6ZKM; EM; 2.80 A; K=1-98.
DR PDB; 6ZKN; EM; 2.90 A; K=1-98.
DR PDB; 6ZKO; EM; 3.80 A; K=1-98.
DR PDB; 6ZKP; EM; 3.20 A; K=1-98.
DR PDB; 6ZKQ; EM; 3.30 A; K=1-98.
DR PDB; 6ZKR; EM; 3.50 A; K=1-98.
DR PDB; 6ZKS; EM; 3.10 A; K=1-98.
DR PDB; 6ZKT; EM; 2.80 A; K=1-98.
DR PDB; 6ZKU; EM; 3.00 A; K=1-98.
DR PDB; 6ZKV; EM; 2.90 A; K=1-98.
DR PDBsum; 5LNK; -.
DR PDBsum; 6Q9B; -.
DR PDBsum; 6QA9; -.
DR PDBsum; 6QBX; -.
DR PDBsum; 6QC2; -.
DR PDBsum; 6QC3; -.
DR PDBsum; 6QC4; -.
DR PDBsum; 6QC5; -.
DR PDBsum; 6QC6; -.
DR PDBsum; 6QC7; -.
DR PDBsum; 6QC8; -.
DR PDBsum; 6QC9; -.
DR PDBsum; 6QCA; -.
DR PDBsum; 6QCF; -.
DR PDBsum; 6ZKA; -.
DR PDBsum; 6ZKB; -.
DR PDBsum; 6ZKC; -.
DR PDBsum; 6ZKD; -.
DR PDBsum; 6ZKE; -.
DR PDBsum; 6ZKF; -.
DR PDBsum; 6ZKG; -.
DR PDBsum; 6ZKH; -.
DR PDBsum; 6ZKI; -.
DR PDBsum; 6ZKJ; -.
DR PDBsum; 6ZKK; -.
DR PDBsum; 6ZKL; -.
DR PDBsum; 6ZKM; -.
DR PDBsum; 6ZKN; -.
DR PDBsum; 6ZKO; -.
DR PDBsum; 6ZKP; -.
DR PDBsum; 6ZKQ; -.
DR PDBsum; 6ZKR; -.
DR PDBsum; 6ZKS; -.
DR PDBsum; 6ZKT; -.
DR PDBsum; 6ZKU; -.
DR PDBsum; 6ZKV; -.
DR AlphaFoldDB; O78754; -.
DR SMR; O78754; -.
DR STRING; 9940.ENSOARP00000000009; -.
DR Ensembl; ENSOART00000000027; ENSOARP00000000009; ENSOARG00000000027.
DR GeneID; 808256; -.
DR KEGG; oas:808256; -.
DR CTD; 4539; -.
DR eggNOG; KOG4669; Eukaryota.
DR HOGENOM; CLU_182394_0_0_1; -.
DR OMA; YRSHLMS; -.
DR OrthoDB; 1538435at2759; -.
DR Proteomes; UP000002356; Mitochondrion.
DR Bgee; ENSOARG00000000027; Expressed in adult mammalian kidney and 54 other tissues.
DR ExpressionAtlas; O78754; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..98
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000118490"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 3..19
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 26..51
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 55..58
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 59..85
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 90..92
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 95..97
FT /evidence="ECO:0007829|PDB:6ZKA"
SQ SEQUENCE 98 AA; 10837 MW; EC0C943C752F8691 CRC64;
MSLVYMNIMM AFTVSLTGLL MYRSHLMSSL LCLEGMMLSL FILATLMILN SHFTLASMMP
IILLVFAACE AALGLSLLVM VSNTYGTDYV QNLNLLQC
