NU4LM_STRCA
ID NU4LM_STRCA Reviewed; 98 AA.
AC O21405;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS Struthio camelus (Common ostrich).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=8801;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9214748; DOI=10.1093/oxfordjournals.molbev.a025815;
RA Harlid A., Janke A., Arnason U.;
RT "The mtDNA sequence of the ostrich and the divergence between paleognathous
RT and neognathous birds.";
RL Mol. Biol. Evol. 14:754-761(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11370967; DOI=10.1098/rspb.2001.1587;
RA Haddrath O., Baker A.J.;
RT "Complete mitochondrial DNA genome sequences of extinct birds: ratite
RT phylogenetics and the vicariance biogeography hypothesis.";
RL Proc. R. Soc. B 268:939-945(2001).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; Y12025; CAA72752.1; -; Genomic_DNA.
DR EMBL; AF338715; AAK53355.1; -; Genomic_DNA.
DR PIR; A99613; A99613.
DR PIR; T11527; T11527.
DR RefSeq; NP_115449.1; NC_002785.1.
DR AlphaFoldDB; O21405; -.
DR SMR; O21405; -.
DR GeneID; 803274; -.
DR CTD; 4539; -.
DR OrthoDB; 1538435at2759; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..98
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000118493"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 98 AA; 10697 MW; 01AD572CE52B99D5 CRC64;
MSFLHLSFYS AFTLSSLGLA FHRTHLISAL LCLESMMLSL YLALSIWPVQ AQTPSFTLVP
ILMLAFSACE AGTGLAMLVA STRTHGSDHL HNLNLLQC
