ID   NU4LM_VARVV             Reviewed;          98 AA.
AC   Q8HBG1; Q8HQ95;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS   Varecia variegata variegata (Black and white ruffed lemur).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Lemuridae; Varecia.
OX   NCBI_TaxID=87289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate JP131, Isolate JP132, and Isolate JP30;
RX   PubMed=12719521; DOI=10.1073/pnas.1031673100;
RA   Pastorini J., Thalmann U., Martin R.D.;
RT   "A molecular approach to comparative phylogeography of extant Malagasy
RT   lemurs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:5879-5884(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate FAN21;
RA   Louis E.E. Jr., Coles M.S., Andriantompohavana R., Sommer J.A.,
RA   Engberg S.E., Zaonarivelo J.R., Mayor M.I., Brenneman R.A.;
RT   "Revision of the mouse lemurs (Microcebus) of Eastern Madagascar.";
RL   Int. J. Primatol. 27:347-389(2006).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. {ECO:0000250|UniProtKB:P03902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03902}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR   EMBL; AF224585; AAN64791.1; -; Genomic_DNA.
DR   EMBL; AF224586; AAN64795.1; -; Genomic_DNA.
DR   EMBL; AF224587; AAN64799.1; -; Genomic_DNA.
DR   EMBL; AY582555; AAT35883.1; -; Genomic_DNA.
DR   RefSeq; YP_002929459.1; NC_012773.1.
DR   AlphaFoldDB; Q8HBG1; -.
DR   SMR; Q8HBG1; -.
DR   GeneID; 7944456; -.
DR   CTD; 4539; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..98
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000275148"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         39
FT                   /note="S -> A (in strain: Isolate JP132)"
SQ   SEQUENCE   98 AA;  10830 MW;  9C5FF9E1E7615FDA CRC64;
     MPSIFINIIL AFIIALLGML IFRSHLMSSL LCLESMMLSM FILSTLTILS LHLTMSFMMP
     ILLLVFAACE AAVGLALLVT VSNTYGLDYI QNLNLLQC