NU4LM_VICPA
ID NU4LM_VICPA Reviewed; 98 AA.
AC Q9MEI2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4L;
GN Name=MT-ND4L; Synonyms=MTND4L, NADH4L, ND4L;
OS Vicugna pacos (Alpaca) (Lama pacos).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Vicugna.
OX NCBI_TaxID=30538;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Ursing B.M., Slack K.E., Arnason U.;
RT "Subordinal artiodactyl relationships in the light of phylogenetic analysis
RT of 12 mitochondrial protein-coding genes.";
RL Zool. Scr. 29:83-88(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15177677; DOI=10.1016/j.gene.2004.02.010;
RA Arnason U., Gullberg A., Janke A.;
RT "Mitogenomic analyses provide new insights into cetacean origin and
RT evolution.";
RL Gene 333:27-34(2004).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. {ECO:0000250|UniProtKB:P03902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03902}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03902}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR EMBL; Y19184; CAC00510.1; -; Genomic_DNA.
DR EMBL; AJ566364; CAD98821.1; -; Genomic_DNA.
DR RefSeq; NP_063909.1; NC_002504.1.
DR AlphaFoldDB; Q9MEI2; -.
DR SMR; Q9MEI2; -.
DR Ensembl; ENSVPAT00000018141; ENSVPAP00000011817; ENSVPAG00000018154.
DR GeneID; 809422; -.
DR CTD; 4539; -.
DR HOGENOM; CLU_182394_0_0_1; -.
DR OMA; YRSHLMS; -.
DR OrthoDB; 1538435at2759; -.
DR Proteomes; UP000504605; Mitochondrion MT.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR PANTHER; PTHR11434; PTHR11434; 1.
DR Pfam; PF00420; Oxidored_q2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..98
FT /note="NADH-ubiquinone oxidoreductase chain 4L"
FT /id="PRO_0000275037"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 98 AA; 10856 MW; 232BE93BCE5E92A7 CRC64;
MSMVYMNIML AFTMSLIGLL MYRSHLMSSL LCLEGMMLSL FVMASLMILS THFTLASMMP
IILLVFAACE AALGLALLVM ISNTYGTDYV QNLNLLQC
