ID   NU4LM_YARLI             Reviewed;          89 AA.
AC   Q9B6D4;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 4L;
GN   Name=ND4L;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX   DOI=10.1002/cfg.72;
RA   Kerscher S., Durstewitz G., Casaregola S., Gaillardin C., Brandt U.;
RT   "The complete mitochondrial genome of Yarrowia lipolytica.";
RL   Comp. Funct. Genomics 2:80-90(2001).
RN   [2]
RP   SUBUNIT.
RX   PubMed=15282186; DOI=10.1016/j.bbabio.2004.04.019;
RA   Abdrakhmanova A., Zickermann V., Bostina M., Radermacher M., Schagger H.,
RA   Kerscher S., Brandt U.;
RT   "Subunit composition of mitochondrial complex I from the yeast Yarrowia
RT   lipolytica.";
RL   Biochim. Biophys. Acta 1658:148-156(2004).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBUNIT: Complex I is composed of 37 different subunits.
CC       {ECO:0000269|PubMed:15282186}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family. {ECO:0000305}.
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DR   EMBL; AJ307410; CAC28106.2; -; Genomic_DNA.
DR   RefSeq; NP_075439.2; NC_002659.1.
DR   PDB; 4WZ7; X-ray; 3.60 A; L=1-89.
DR   PDB; 6GCS; EM; 4.32 A; L=1-86.
DR   PDB; 6H8K; X-ray; 3.79 A; L=1-79.
DR   PDB; 6RFQ; EM; 3.30 A; L=1-89.
DR   PDB; 6RFR; EM; 3.20 A; L=1-89.
DR   PDB; 6RFS; EM; 4.04 A; L=1-89.
DR   PDB; 6Y79; EM; 3.20 A; L=1-89.
DR   PDB; 6YJ4; EM; 2.70 A; K=1-89.
DR   PDBsum; 4WZ7; -.
DR   PDBsum; 6GCS; -.
DR   PDBsum; 6H8K; -.
DR   PDBsum; 6RFQ; -.
DR   PDBsum; 6RFR; -.
DR   PDBsum; 6RFS; -.
DR   PDBsum; 6Y79; -.
DR   PDBsum; 6YJ4; -.
DR   AlphaFoldDB; Q9B6D4; -.
DR   SMR; Q9B6D4; -.
DR   DIP; DIP-61440N; -.
DR   IntAct; Q9B6D4; 2.
DR   STRING; 284591.Q9B6D4; -.
DR   GeneID; 802609; -.
DR   KEGG; yli:YalifMp19; -.
DR   InParanoid; Q9B6D4; -.
DR   Proteomes; UP000001300; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   PANTHER; PTHR11434; PTHR11434; 1.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Electron transport; Membrane; Mitochondrion; NAD;
KW   Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..89
FT                   /note="NADH-ubiquinone oxidoreductase chain 4L"
FT                   /id="PRO_0000118501"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   HELIX           2..16
FT                   /evidence="ECO:0007829|PDB:6YJ4"
FT   HELIX           23..47
FT                   /evidence="ECO:0007829|PDB:6YJ4"
FT   HELIX           51..81
FT                   /evidence="ECO:0007829|PDB:6YJ4"
SQ   SEQUENCE   89 AA;  9811 MW;  6975542DC42FA175 CRC64;
     MFIGTIILVL SFLGFVFNRR NIILAFICLE TMLLGINLIL LRNSVLFDDI SGSLFAIVII
     ILAGVESAIG LSLLVSYYRL RGVINSYGI