ID   AROQ_AMYME              Reviewed;          20 AA.
AC   P46380;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=3-dehydroquinate dehydratase;
DE            Short=3-dehydroquinase;
DE            EC=4.2.1.10;
DE   AltName: Full=Type II DHQase;
DE   Flags: Fragment;
GN   Name=aroQ;
OS   Amycolatopsis methanolica.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Amycolatopsis; Amycolatopsis methanolica group.
OX   NCBI_TaxID=1814;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=DSM 44096 / JCM 8087 / NBRC 15065 / NCIMB 11946 / NRRL B-24139 / LMD
RC   80.32 / 239;
RX   PubMed=1479361; DOI=10.1099/00221287-138-11-2449;
RA   Euverink G.J.W., Hessels G.I., Vrijbloed J.W., Coggins J.R., Dijkhuizen L.;
RT   "Purification and characterization of a dual function 3-dehydroquinate
RT   dehydratase from Amycolatopsis methanolica.";
RL   J. Gen. Microbiol. 138:2449-2457(1992).
CC   -!- FUNCTION: Catalyzes a trans-dehydration via an enolate intermediate. Is
CC       involved in both the catabolism of quinate and the biosynthesis of
CC       aromatic amino acids.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-dehydroquinate = 3-dehydroshikimate + H2O;
CC         Xref=Rhea:RHEA:21096, ChEBI:CHEBI:15377, ChEBI:CHEBI:16630,
CC         ChEBI:CHEBI:32364; EC=4.2.1.10;
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 9.0.;
CC       Temperature dependence:
CC         Optimum temperature is 76 degrees Celsius. Thermostable.;
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       3/7.
CC   -!- SUBUNIT: Homododecamer.
CC   -!- SIMILARITY: Belongs to the type-II 3-dehydroquinase family.
CC       {ECO:0000305}.
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DR   PIR; A47687; A47687.
DR   AlphaFoldDB; P46380; -.
DR   BioCyc; MetaCyc:MON-15327; -.
DR   UniPathway; UPA00053; UER00086.
DR   GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019630; P:quinate metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.9100; -; 1.
DR   InterPro; IPR036441; DHquinase_II_sf.
DR   SUPFAM; SSF52304; SSF52304; 1.
PE   1: Evidence at protein level;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Direct protein sequencing; Lyase; Quinate metabolism.
FT   CHAIN           1..>20
FT                   /note="3-dehydroquinate dehydratase"
FT                   /id="PRO_0000159865"
FT   SITE            17
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000250"
FT   NON_TER         20
SQ   SEQUENCE   20 AA;  2197 MW;  C24AA183E5CFDF0A CRC64;
     MKVFVLNGPN LGRLGKREPA