NU4M_MACFA
ID NU4M_MACFA Reviewed; 152 AA.
AC P50664;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4;
DE Flags: Fragment;
GN Name=MT-ND4; Synonyms=MTND4, NADH4, ND4;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3146681; DOI=10.1093/oxfordjournals.molbev.a040524;
RA Hayasaka K., Gojobori T., Horai S.;
RT "Molecular phylogeny and evolution of primate mitochondrial DNA.";
RL Mol. Biol. Evol. 5:626-644(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8752012; DOI=10.1093/oxfordjournals.molbev.a025655;
RA Hayasaka K., Fujii K., Horai S.;
RT "Molecular phylogeny of macaques: implications of nucleotide sequences from
RT an 896-base pair region of mitochondrial DNA.";
RL Mol. Biol. Evol. 13:1044-1053(1996).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
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DR EMBL; M22653; AAA69757.1; -; Genomic_DNA.
DR EMBL; D85275; BAA12761.1; -; Genomic_DNA.
DR PIR; I77325; I77325.
DR AlphaFoldDB; P50664; -.
DR SMR; P50664; -.
DR Proteomes; UP000233100; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN <1..152
FT /note="NADH-ubiquinone oxidoreductase chain 4"
FT /id="PRO_0000117951"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT NON_TER 1
SQ SEQUENCE 152 AA; 17097 MW; 62668B61304FE09A CRC64;
SFSGATTLMI AHGLTSSMYF CLANSNYERT HNRTMLLSRG LQILLPLTAF WWLTASLTNL
ALPPTINLLG ELFVITTSFS WSHITIVLTG LNMLITALYS LHMFITVQRG TLTHHMINMK
PPFTRENMLM FMHLAPIILL SLNPNIILGF TS
