NU4M_MARPO
ID NU4M_MARPO Reviewed; 495 AA.
AC P26848;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4;
GN Name=ND4; Synonyms=NAD4;
OS Marchantia polymorpha (Liverwort) (Marchantia aquatica).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Marchantiophyta;
OC Marchantiopsida; Marchantiidae; Marchantiales; Marchantiaceae; Marchantia.
OX NCBI_TaxID=3197;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1731062; DOI=10.1016/0022-2836(92)90708-r;
RA Oda K., Yamato K., Ohta E., Nakamura Y., Takemura M., Nozato N., Akashi K.,
RA Kanegae T., Ogura Y., Kohchi T., Ohyama K.;
RT "Gene organization deduced from the complete sequence of liverwort
RT Marchantia polymorpha mitochondrial DNA. A primitive form of plant
RT mitochondrial genome.";
RL J. Mol. Biol. 223:1-7(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8483448; DOI=10.1007/bf00279437;
RA Nozato N., Oda K., Yamato K., Ohta E., Takemura M., Akashi K., Fukuzawa H.,
RA Ohyama K.;
RT "Cotranscriptional expression of mitochondrial genes for subunits of NADH
RT dehydrogenase, nad5, nad4, nad2, in Marchantia polymorpha.";
RL Mol. Gen. Genet. 237:343-350(1993).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M68929; AAC09398.1; -; Genomic_DNA.
DR PIR; S25942; S25942.
DR RefSeq; NP_054401.1; NC_001660.1.
DR AlphaFoldDB; P26848; -.
DR SMR; P26848; -.
DR GeneID; 2702661; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009536; C:plastid; IEA:UniProt.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
DR TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..495
FT /note="NADH-ubiquinone oxidoreductase chain 4"
FT /id="PRO_0000117953"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 495 AA; 56311 MW; 0F75894D6CAAAED4 CRC64;
MLQVLAPFYS NLSGLILLPL LGSLIILVIP NSRVRLIRGI TIWTSLITFL YSLFFWIRFE
NDTAKFQFVE TIRWLPYSNI NFYIGIDGIS LFFVILTTFL TPICILVGFY SVKSYKKEYM
IAFFICESFL IAVFCSLDLL IFYVFFESVL IPMFIIIGVW GSRQRKIKAA YQFFLYTLMG
SLFMLLAILF IFFQTGTTDL QILLTTEFSE RRQILLWIAF FASFSVKVPM VPVHIWLPEA
HVEAPTAGSV ILAGILLKLG TYGFLRFSIP MFPEATLYFT PFIYTLSVIA IIYTSLTTIR
QIDLKKIIAY SSVAHMNFVT IGMFSLNIQG IEGSILLMLS HGLVSSALFL CVGALYDRHK
TRIVKYYGGL VSTMPIFSTI FLFFTLANMS LPGTSSFIGE FLILVGAFQR NSLVATLAAL
GMILGAAYSL WLYNRVVFGN FKPNFILKFS DLNRREVLIF LPFIVGVIWM GVYPEVFLEC
MHTSVSNLVQ HGKFD
