NU4M_MICSI
ID NU4M_MICSI Reviewed; 459 AA.
AC Q591M5;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03905};
DE AltName: Full=NADH dehydrogenase subunit 4;
GN Name=MT-ND4; Synonyms=MTND4, NADH4, ND4;
OS Microcebus simmonsi (Simmons's mouse lemur).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Cheirogaleidae; Microcebus.
OX NCBI_TaxID=236272;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate BET29, Isolate BET35, Isolate BET39, Isolate BET87,
RC Isolate PBZT117, Isolate ZAH12, Isolate ZAH2, Isolate ZAH5, and
RC Isolate ZAH7;
RA Louis E.E. Jr., Coles M.S., Andrianompohavana R., Sommer J.A., Mayor M.I.,
RA Brenneman R.A.;
RT "Revision of the mouse lemurs (Primates, Microcebus) in Eastern Madagascar
RT with the description of three new species.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03905}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03905};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03910}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03910}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
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DR EMBL; AY582663; AAS92844.1; -; Genomic_DNA.
DR EMBL; AY582664; AAS92848.1; -; Genomic_DNA.
DR EMBL; AY582665; AAS92852.1; -; Genomic_DNA.
DR EMBL; AY582666; AAS92856.1; -; Genomic_DNA.
DR EMBL; AY582667; AAS92860.1; -; Genomic_DNA.
DR EMBL; AY582668; AAS92864.1; -; Genomic_DNA.
DR EMBL; AY582669; AAS92868.1; -; Genomic_DNA.
DR EMBL; AY582670; AAS92872.1; -; Genomic_DNA.
DR EMBL; AY582671; AAS92876.1; -; Genomic_DNA.
DR AlphaFoldDB; Q591M5; -.
DR SMR; Q591M5; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR000260; NADH4_N.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF01059; Oxidored_q5_N; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
DR TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..459
FT /note="NADH-ubiquinone oxidoreductase chain 4"
FT /id="PRO_0000256685"
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 459 AA; 52313 MW; 8118019DB1A0C302 CRC64;
MLKIIIPTIM LFPVIWYSNG NMIWINTTSY SLMISLMTLP LLNQTENNSN NFSLMFFSDS
LSSPLLMLTV WLLPLMIMAS QHHLTKEPLM RKKLYLSMLT FLQMFLIMTF TATELILFYI
LFEATLIPTL IIITRWGNQT ERLNAGLYFL FYTLIGSLPL LVALIYVQNS LGSLNYLVMN
MWSQDTSSLW SSNLLWLACI MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG
YGMLRLTMIL NPTTKIMAYP FIMLCLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA
ILMQTPWSFM GATALMIAHG LTSSMLFCLA NSNYERIHSR TMLLARGLQA FLPLMATWWL
LASLTNLALP PFINLIGELF VIMASFSWSN LTIIMTGLNM LITALYSLYM LTMTQRGKFT
YHIYNIKPSY TRENTLMSMH MLPLIMLTFN PKIIMGLTY
