NU4M_MYTED
ID NU4M_MYTED Reviewed; 435 AA.
AC Q00231; Q68SR4;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4;
GN Name=ND4;
OS Mytilus edulis (Blue mussel).
OG Mitochondrion.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC Mytilus.
OX NCBI_TaxID=6550;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO 293-294.
RX PubMed=15014161; DOI=10.1093/molbev/msh090;
RA Boore J.L., Medina M., Rosenberg L.A.;
RT "Complete sequences of the highly rearranged molluscan mitochondrial
RT genomes of the scaphopod Graptacme eborea and the bivalve Mytilus edulis.";
RL Mol. Biol. Evol. 21:1492-1503(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-145 AND 294-435.
RX PubMed=1386586; DOI=10.1093/genetics/131.2.397;
RA Hoffmann R.J., Boore J.L., Brown W.M.;
RT "A novel mitochondrial genome organization for the blue mussel, Mytilus
RT edulis.";
RL Genetics 131:397-412(1992).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
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DR EMBL; AY484747; AAT98410.1; -; Genomic_DNA.
DR PIR; S28751; S28751.
DR RefSeq; YP_073339.1; NC_006161.1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..435
FT /note="NADH-ubiquinone oxidoreductase chain 4"
FT /id="PRO_0000117958"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 435 AA; 47027 MW; F0B78CCD49BEB9CE CRC64;
MVKSLAISLI ALIIMKNLNV SIIGLSVLTI LSMGAASVAT GGVELNGLYS TDFVMGLMIT
LTLFVAILSY LSSAKVSRKA SFNLMVISIS LILVMSFSVS SFFLFFFFFE SVLAPLLLLI
VGWGYQPERL QAGGYMVIYT VFGSLFFLWG VSELYLSGMS SSMSSVGSLV KKSAMSLWWL
YILGFLIKLP MYPFHLWLPK AHVEAPVAGS MLLAGVVLKL GGYGLLRFML VMQVSLSSVF
FVLLLSVNLA GGFYAGLACV RQVDLKCLVA YSSVAHMSLV LLGVLSNTLL GVMGAIIIMV
GHGLCSSGLF SYVNAIYKMS HSRLLVMNKG GXLFCPVLVL MCFLLSSSNM AAPPSLNLFG
EILVFGVGGX XSXAFLFILG LMSFISACFS LYLYGSCSHG KGLMHSESLN LSSLCDVFVL
LSHWVPLNFL FMFMP
