NU4M_PANTR
ID NU4M_PANTR Reviewed; 459 AA.
AC P03906; Q9T9V7;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03905};
DE AltName: Full=NADH dehydrogenase subunit 4;
GN Name=MT-ND4; Synonyms=MTND4, NADH4, ND4;
OS Pan troglodytes (Chimpanzee).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7530363; DOI=10.1073/pnas.92.2.532;
RA Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
RT "Recent African origin of modern humans revealed by complete sequences of
RT hominoid mitochondrial DNAs.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 308-459.
RX PubMed=6284948; DOI=10.1007/bf01734101;
RA Brown W.M., Prager E.M., Wang A., Wilson A.C.;
RT "Mitochondrial DNA sequences of primates: tempo and mode of evolution.";
RL J. Mol. Evol. 18:225-239(1982).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03905}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03905};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03910}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03910}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
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DR EMBL; D38113; BAA85274.1; -; Genomic_DNA.
DR EMBL; V00672; CAB51801.1; ALT_TERM; Genomic_DNA.
DR PIR; A00435; A00435.
DR RefSeq; NP_008195.1; NC_001643.1.
DR AlphaFoldDB; P03906; -.
DR SMR; P03906; -.
DR STRING; 9598.ENSPTRP00000061398; -.
DR PaxDb; P03906; -.
DR Ensembl; ENSPTRT00000076403; ENSPTRP00000061398; ENSPTRG00000042639.
DR GeneID; 807863; -.
DR KEGG; ptr:807863; -.
DR CTD; 4538; -.
DR VGNC; VGNC:11721; MT-ND4.
DR eggNOG; KOG4845; Eukaryota.
DR GeneTree; ENSGT00730000111316; -.
DR HOGENOM; CLU_007100_4_0_1; -.
DR InParanoid; P03906; -.
DR OMA; ITRWGNQ; -.
DR OrthoDB; 996580at2759; -.
DR Proteomes; UP000002277; Mitochondrion.
DR Bgee; ENSPTRG00000042639; Expressed in cortex of kidney and 21 other tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0048039; F:ubiquinone binding; IBA:GO_Central.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR000260; NADH4_N.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF01059; Oxidored_q5_N; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
DR TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..459
FT /note="NADH-ubiquinone oxidoreductase chain 4"
FT /id="PRO_0000117963"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 327
FT /note="S -> F (in Ref. 2; CAB51801)"
FT /evidence="ECO:0000305"
FT CONFLICT 425
FT /note="S -> N (in Ref. 2; CAB51801)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 459 AA; 51648 MW; EAD99B73D33A6190 CRC64;
MLKLIIPTIM LLPLTWFSKK RMIWINTTTH SLIISTIPLL FFNQINNNLF SCSLPFSSDP
LTTPLLMLTA WLLPLTIMAS QRHLSNEPLS RKKLYLSMLI SLQISLIMTF SATELIMFYI
FFETTLIPTL AIITRWGNQP ERLNAGTYFL FYTLVGSLPL LIALIYTHNT LGSLNILLLT
LTTQELSNTW ANNLMWLAYT MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG
YGMMRLTLIL NPLTKHMAYP FLMLSLWGMI MTSSICLRQT DLKSLIAYPS VSHMALVVTA
ILIQTPWSFT GAIILMIAHG LTSSLLSCLA NSNYERTHSR IMILSQGLQT LLPLMAFWWL
LASLANLALP PTINLLGELS VLVTSFSWSN TTLLLTGFNM LITALYSLYM FTTTQWGSLT
HHINSMKPSF TRENTLMFLH LSPILLLSLN PDIITGFTS
