NU4M_PATPE
ID NU4M_PATPE Reviewed; 460 AA.
AC P11992;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4;
GN Name=ND4;
OS Patiria pectinifera (Starfish) (Asterina pectinifera).
OG Mitochondrion.
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC Valvatacea; Valvatida; Asterinidae; Patiria.
OX NCBI_TaxID=7594;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3678836; DOI=10.1016/0378-1119(87)90139-9;
RA Himeno H., Masaki H., Kawai T., Ohta T., Kumagai I., Miura K., Watanabe K.;
RT "Unusual genetic codes and a novel gene structure for tRNA(AGYSer) in
RT starfish mitochondrial DNA.";
RL Gene 56:219-230(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Ovary;
RX PubMed=7672576; DOI=10.1093/genetics/140.3.1047;
RA Asakawa S., Himeno H., Miura K., Watanabe K.;
RT "Nucleotide sequence and gene organization of the starfish Asterina
RT pectinifera mitochondrial genome.";
RL Genetics 140:1047-1060(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
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DR EMBL; M17619; AAA65516.2; -; Genomic_DNA.
DR EMBL; D16387; BAA03874.1; -; Genomic_DNA.
DR PIR; C27311; C27311.
DR RefSeq; NP_008162.1; NC_001627.1.
DR AlphaFoldDB; P11992; -.
DR SMR; P11992; -.
DR GeneID; 807824; -.
DR CTD; 4538; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR000260; NADH4_N.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF01059; Oxidored_q5_N; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
DR TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..460
FT /note="NADH-ubiquinone oxidoreductase chain 4"
FT /id="PRO_0000117895"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 460 AA; 50787 MW; 5731114913473C47 CRC64;
MIYLILTSTL TLATTWIVPR NLLWPSSILN SILISVISLN LLNNHSTSLW HNLSLNFATD
PTSTPLIILS SWLVPISLIA SINTIQNHNH INQRTFISLV FTILTALILT FSSLELSLFY
IAFETTLLPT LTLISRWGAQ KERYQASIYF LFYTLIGSLP LLVSIIAIFS YENTIILPSI
HLTNYITSLP ITLTSIWWIF CFIAFIIKMP IYGFHLWLPK AHVEAPIAGS MILAAILLKL
GGYGLLRTIP LFYTPSSLLL SPPATAFCIW GALITSIICL RQTDLKALIA YSSVGHMSIV
ASGIFSLSLW GINGALTLMI AHGLISSALF CLANLLYERN GTRTLSITRG FKMVTPLLTL
WWTITCVANL GLPPTPNLIG ELLILVAIID WNTLSAPIIT MATVFGAIYS LLILSSTNNS
SFPQFLSNIQ PTNTSEHTLI TFHLIPLVFL ILNPSAILIG
