NU4M_SALSA
ID NU4M_SALSA Reviewed; 460 AA.
AC Q9ZZM4; Q9MPG7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 4;
GN Name=MT-ND4; Synonyms=MTND4, NADH4, ND4;
OS Salmo salar (Atlantic salmon).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=10548724; DOI=10.1016/s0378-1119(99)00425-4;
RA Hurst C.D., Bartlett S.E., Davidson W.S., Bruce I.J.;
RT "The complete mitochondrial DNA sequence of the Atlantic salmon, Salmo
RT salar.";
RL Gene 239:237-242(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Arnason U., Johnsson E., Rasmussen A.S.;
RT "The complete mitochondrial genome sequence of a teleost, Salmo salar, and
RT comparisons with other salmoniformes.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. {ECO:0000305}.
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DR EMBL; U12143; AAD04742.1; -; Genomic_DNA.
DR EMBL; AF133701; AAF61387.1; -; Genomic_DNA.
DR PIR; T09956; T09956.
DR RefSeq; NP_008454.1; NC_001960.1.
DR AlphaFoldDB; Q9ZZM4; -.
DR SMR; Q9ZZM4; -.
DR STRING; 8030.ENSSSAP00000000011; -.
DR GeneID; 808305; -.
DR KEGG; sasa:808305; -.
DR CTD; 4538; -.
DR OMA; ITRWGNQ; -.
DR OrthoDB; 996580at2759; -.
DR Proteomes; UP000087266; Mitochondrion MT.
DR Bgee; ENSSSAG00000000029; Expressed in zone of skin and 16 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR000260; NADH4_N.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR43507; PTHR43507; 1.
DR Pfam; PF01059; Oxidored_q5_N; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
DR TIGRFAMs; TIGR01972; NDH_I_M; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..460
FT /note="NADH-ubiquinone oxidoreductase chain 4"
FT /id="PRO_0000117984"
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 193
FT /note="N -> D (in Ref. 2; AAF61387)"
FT /evidence="ECO:0000305"
FT CONFLICT 210
FT /note="V -> L (in Ref. 2; AAF61387)"
FT /evidence="ECO:0000305"
FT CONFLICT 353
FT /note="L -> V (in Ref. 2; AAF61387)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 460 AA; 51552 MW; 2919547E0DDC72EB CRC64;
MLKILIPTLM LFPTIWFSPA KWLWTTSIAQ SLVIALASLS WLKWSSETGW SSSNLYLATD
PLSTPLLVLT CWLLPLMVLA SQNHISPEPL NRQRTYISLL VSLQMFLILA FGATEIIMFY
IMFEATLLPT LIIITRWGNQ TERLNAGTYF LFYTLAGSLP LLVALLLLQN DSGTLSMFTL
QYTQPMHLLT WGNKLWWAAC LLAFLVKMPV YGVHLWLPKA HVEAPIAGSM ILAAVLLKLG
GYGMMRMMVM LDPLTKELAY PFIVLALWGI IMTGSICLRQ TDLKSLIAYS SVGHMGLVAG
GILIQTPWGF TGAIILMIAH GLASSALFCL ANTSYERTHS RTMLLARGMQ MILPLMTTWW
FVASLANLAL PPLPNLMGEL MIITSMFNWS HWTLLLTGLG TLITASYSLY LFLMTQRGPL
PSHIIALEPT HTREHLLITL HLIPIILLIL KPELMWGWCF
